Semi-interpenetrating network of acrylamide-grafted-sodium alginate microspheres for controlled release of diclofenac sodium, preparation and characterization

Colloids and Surfaces. B, Biointerfaces
Ahmed A Al-Kahtani, B S Sherigara

Abstract

The semi-interpenetrating networks (semi-IPNs) of acrylamide grafted sodium alginate (AAm-g-NaAlg) microspheres (MPs) were prepared by emulsion-crosslinking method using glutaraldehyde (GA) as a crosslinking agent. The grafting of acrylamide onto sodium alginate was prepared by free-radical graft polymerization using ceric ammonium nitrate (CAN) as initiator at three acrylamide concentrations with monomer to polymer ratio of 1:1, 2:1 and 3:1, respectively. The grafting efficiency was found to be 91%. The produced MPs are almost spherical in nature with smooth surfaces. Diclofenac sodium (DS), an anti-inflammatory drug was successfully encapsulated into the MPs. The encapsulation efficiency was found to vary between 83% and 95%. The MPs were characterized by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The diffusion coefficient (D) was dependent upon the amount of crosslinking agent (GA) and amount of grafting ratio in the matrix. The rate of release was found to be dependent on the amount of GA, AAm:NaAlg grafting ratio and % drug loading in the MPs. The release data have been fitted to an empirical equation to investigate the diffusional exponen...Continue Reading

References

Sep 1, 1990·Bio/technology·W C Skarnes
Sep 1, 1993·Journal of Pharmaceutical Sciences·M RajaonarivonyP Couvreur
Dec 30, 1998·Archives of Pharmacal Research·B J LeeC K Kim
Dec 17, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hsu-Ko KuoLewis A Lipsitz

❮ Previous
Next ❯

Citations

Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·De-Ying TianXiao-Dong Li
Mar 2, 2016·Colloids and Surfaces. B, Biointerfaces·Agnieszka KierysJacek Goworek
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Chao-Fan DaiXiao-Dong Li
Oct 20, 2015·International Journal of Biological Macromolecules·Salah M Tawfik, Hassan H Hefni
Mar 22, 2016·International Journal of Pharmaceutics·De-Ying TianZhao-Lin Sha
May 20, 2015·International Journal of Biological Macromolecules·Priyanka SinhaBobba Rama
Sep 1, 2016·Carbohydrate Polymers·Xiaoju ZhouXianming Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.