Semi-interpenetrating polymer networks composed of silk fibroin and poly(ethylene glycol) for wound dressing

Biomedical Materials
Hae Yong KweonChong-Su Cho

Abstract

Semi-interpenetrating polymer networks (SIPNs) composed of silk fibroin (SF) and poly(ethylene glycol) (PEG) were prepared by photopolymerization of a PEG macromer in the presence of SF to improve the mechanical properties of SF sponge as wound dressing. The morphological structure of the SF/PEG SIPNs was observed to be composed of an interconnected microporous surface and a cross-sectional area. SF/PEG SIPNs showed non-cytotoxicity evaluated by a cell proliferation method using L929 fibroblasts. Wound contraction treated with SF/PEG SIPNs sponges was faster than that of Vaseline gauze as a control. Histological observation confirmed that the deposition of collagen in the dermis was organized by covering the wound area with SF/PEG SIPNs. The above results indicated that SF/PEG SIPNs could be used as wound dressing.

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Citations

May 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Mariana Agostini de MoraesMarisa Masumi Beppu
Nov 26, 2015·Acta Biomaterialia·Sonia Kapoor, Subhas C Kundu
Nov 7, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jing ChangZhongwei Gu
Mar 31, 2015·Nanomedicine·Omid MashinchianMorteza Mahmoudi
Aug 23, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Ji-Young SongJwa-Young Kim
Dec 24, 2010·Journal of Biomaterials Science. Polymer Edition·Sijia MinJuming Yao
Nov 17, 2009·Expert Review of Medical Devices·Brett LevinMarcus David Atlas
Nov 14, 2013·The Journal of Craniofacial Surgery·Sang-Woon LeeByoung-Eun Yang
May 1, 2014·Maxillofacial Plastic and Reconstructive Surgery·Min-Keun KimHae-Yong Kweon
Dec 6, 2019·Acta Biomaterialia·Dimple Chouhan, Biman B Mandal

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