Semi-quantitative gallium-67 lung scanning as a measure of the intensity of alveolitis in pulmonary sarcoidosis

European Journal of Nuclear Medicine
G J DuffyM X Fitzgerald

Abstract

Gallium-67 (67Ga) lung scanning has been applied for some years in pulmonary sarcoidosis to assess the activity of the alveolitis. Interpreting the scans, however, is difficult due to the low uptake of 67Ga in the disease process relative to background activity. In this study we have measured the mean parenchymal lung activity of 67Ga and have compared the lung activity to that at three remote sites, the liver, the abdomen and the thigh. The results obtained were compared with the percentage of lymphocytes in broncho-alveolar lavage fluid. There was a very good correlation with the lung-to-thigh uptake measurements and a much poorer correlation with the lung-to-liver and the lung-to-abdomen measurements. It was observed that steroid therapy reduced dramatically the correlation between the broncho-alveolar lavage findings and the 67Ga scan measurements. The results suggest that in patients not on steroid therapy, the 67Ga lung-to-thigh measurements may be used, similarly to the broncho-alveolar lavage lymphocyte counts, to identify those with high-intensity alveolitis from those with low-intensity alveolitis.

References

Dec 1, 1974·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·A HeshikiH N Wagner
Apr 1, 1984·AJR. American Journal of Roentgenology·W A FajmanE C McClees
Mar 1, 1981·The American Journal of Medicine·R G CrystalG W Hunninghake
Jan 1, 1981·European Journal of Nuclear Medicine·C AlbertsA S Groen

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Citations

Jan 1, 1989·Irish Journal of Medical Science·D M GilliganM X FitzGerald
Jul 1, 1989·Annals of Nuclear Medicine·M Kataoka
Oct 21, 2016·Expert Review of Clinical Immunology·Amit ChopraMarc A Judson
Nov 1, 1991·World Journal of Surgery·T Obara, Y Fujimoto

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