Semi-solid extrusion 3D printing ODFs: an individual drug delivery system for small scale pharmacy.

Drug Development and Industrial Pharmacy
Ting-Ting YanYan-Zhong Chen

Abstract

Orodispersible films (ODFs) are promising drug delivery systems for customized medicines as it provide an alternative approach to increase consumer acceptance by advantages of rapid dissolution and administration without water. The aim of this study was to develop a platform to support the realization of tailored treatments suitable for the extemporaneous production of ODFs by semi-solid extrusion (SSE) 3D printing (3DP). Hydroxypropyl methyl cellulose (HPMC) was used as the polymer of ODFs, and levocetirizine hydrochloride was used as the model drug. The optimal formulation was HPMC:API:PS:maltitol:sucralose at a ratio of 64:10:10:15:1. Seventeen percent HPMC solution and optimal formulation were used to prepare film precursors. The impact of dynamic viscosities and fluid mechanics difference on printing applicability was discussed. The ODFs of cube designs with aimed dose of 1.25 mg, 2.5 mg, and 5 mg were printed by SSE 3DP. Good linear relationship between theoretical model volume and drug content (R2 = 0.999) and good dose accuracy indicate that 3DP is a suitable method for preparing individualized ODFs.

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Citations

Jul 28, 2020·Drug Development and Industrial Pharmacy·Melissa WallisAli Nokhodchi
Nov 21, 2020·Pharmaceutics·Patricija JanuskaiteAlvaro Goyanes
Feb 5, 2021·International Journal of Pharmaceutics·Magdalena KuźmińskaMohamed A Alhnan
Mar 3, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Iria Seoane-ViañoAlvaro Goyanes
Mar 12, 2021·Advanced Drug Delivery Reviews·Jhinuk Rahman, Julian Quodbach
Apr 11, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Rishi ThakkarMohammed Maniruzzaman
May 10, 2021·Advanced Drug Delivery Reviews·Iria Seoane-ViañoAlvaro Goyanes
Jul 9, 2021·Advanced Drug Delivery Reviews·Christina KaravasiliDimitrios G Fatouros
Aug 15, 2021·Advanced Drug Delivery Reviews·Georgios K EleftheriadisJukka Rantanen
Sep 4, 2021·Advanced Drug Delivery Reviews·Atheer AwadAbdul W Basit
Sep 15, 2021·Expert Opinion on Drug Delivery·Sujit Kumar DebnathAbdelwahab Omri

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