Semi-stochastic cell-level computational modelling of cellular forces: application to contractures in burns and cyclic loading

Biomechanics and Modeling in Mechanobiology
F J Vermolen, A Gefen

Abstract

A phenomenological model is formulated to model cellular forces on extracellular material. The model is capable of modelling both expansion and contractile forces. This work is based on the assumption of linear elasticity, which allows a superposition argument to arrive at fundamental expressions for cellular forces. It is also shown how the cellular forces can be implemented using different strategies, as well as an extension to cellular point sources. Illustrations are given for modelling a (permanent) contraction (e.g. a contracture) of burns and for cyclic loading by the cells.

References

Sep 28, 1992·Physical Review Letters·F Graner, J A Glazier
Oct 9, 2008·Journal of Mathematical Biology·Helen Byrne, Dirk Drasdo
Dec 17, 2009·Journal of Mathematical Biology·Andreas Groh, Alfred K Louis
Nov 4, 2010·Biophysical Journal·Christopher A Lemmon, Lewis H Romer
Mar 29, 2011·Biomechanics and Modeling in Mechanobiology·F J Vermolen, A Gefen
Nov 11, 2011·Journal of Mathematical Biology·F J Vermolen, E Javierre
May 25, 2012·Biomechanics and Modeling in Mechanobiology·F J Vermolen, A Gefen
Aug 15, 2014·PLoS Computational Biology·René F M van OersRoeland M H Merks

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Citations

Jan 26, 2016·Journal of Biomechanics·W M BoonF J Vermolen
Apr 3, 2016·Biomechanics and Modeling in Mechanobiology·F D BookholtF J Vermolen
Oct 7, 2016·Interface Focus·Daphne WeihsFred J Vermolen
Feb 7, 2018·Biomechanics and Modeling in Mechanobiology·Shengmao LinLinxia Gu
Jul 6, 2020·Biomechanics and Modeling in Mechanobiology·Qiyao Peng, Fred Vermolen

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