PMID: 6402522Feb 1, 1983Paper

Semiautomated determination of minimum bactericidal concentrations of antibiotics

Journal of Clinical Pathology
F O'GradyN J Pearson

Abstract

Using a newly devised 50-channel photometer which records the opacity of growing bacterial cultures, it was shown that the time taken by cultures diluted 1/1000 in fresh broth to reach 50% of the opacity of a fully grown culture was inversely related to the concentration of organisms in the original culture. This relation was used to determine the numbers of survivors after exposure to benzylpenicillin and gentamicin alone and in combination. The procedure is commended as a labour-saving and potentially rapid method of obtaining comprehensive information on the bactericidal action and interaction of antibiotics.

References

Mar 1, 1978·The Journal of Antimicrobial Chemotherapy·D Greenwood, F O'Grady
Sep 1, 1981·Journal of Medical Engineering & Technology·T McDonaldF W O'Grady

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Citations

Jan 16, 2004·Bioorganic & Medicinal Chemistry·Maciej CierpuchaMarek Chmielewski
Oct 30, 2007·The Journal of Antibiotics·Maciej CierpuchaJolanta Solecka
Jan 27, 2009·The Journal of Antibiotics·Hum Nath JnawaliJae Kyung Sohng
Aug 1, 1997·Natural Product Reports·K H BaggaleyC J Schofield
Sep 13, 2011·International Journal of Antimicrobial Agents·Boce ZhangQin Wang

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