PMID: 15244626Jul 13, 2004Paper

Semiconservative replication in the quasispecies model

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Emmanuel TannenbaumEugene I Shakhnovich

Abstract

This paper extends Eigen's quasispecies equations to account for the semiconservative nature of DNA replication. We solve the equations in the limit of infinite sequence length for the simplest case of a static, sharply peaked fitness landscape. We show that the error catastrophe occurs when micro, the product of sequence length and per base pair mismatch probability, exceeds 2 ln [2/ ( 1+1/k ) ], where k>1 is the first-order growth rate constant of the viable "master" sequence (with all other sequences having a first-order growth rate constant of 1 ). This is in contrast to the result of ln k for conservative replication. In particular, as k--> infinity, the error catastrophe is never reached for conservative replication, while for semiconservative replication the critical micro approaches 2 ln 2. Semiconservative replication is therefore considerably less robust than conservative replication to the effect of replication errors. We also show that the mean equilibrium fitness of a semiconservatively replicating system is given by k ( 2 e(-micro/2) -1 ) below the error catastrophe, in contrast to the standard result of k e(-micro) for conservative replication (derived by Kimura and Maruyama in 1966). From this result it is readi...Continue Reading

References

Dec 1, 1982·Biophysical Chemistry·J Swetina, P Schuster
Oct 4, 2000·Physical Review Letters·M Nilsson, N Snoad
Jun 21, 2001·Physical Review Letters·S Altmeyer, J S McCaskill
Dec 12, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·R Pastor-Satorras, R V Solé
Mar 23, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Martin Nilsson, Nigel Snoad
Oct 4, 2003·Physical Review Letters·Emmanuel TannenbaumEugene I Shakhnovich
Mar 5, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Emmanuel Tannenbaum, Eugene I Shakhnovich
Dec 1, 1966·Genetics·M Kimura, T Maruyama

❮ Previous
Next ❯

Citations

Dec 15, 2005·Journal of Virology·Jesse Summers, Samuel Litwin
Aug 19, 2005·BMC Evolutionary Biology·Claus O Wilke
Aug 10, 2012·PLoS Computational Biology·C Scott Wylie, Eugene I Shakhnovich
Sep 11, 2008·Genetics·James J Bull, Claus O Wilke
Jul 25, 2009·Journal of Theoretical Biology·Shelby H Steinmeyer, Claus O Wilke
Nov 1, 2006·Journal of Theoretical Biology·Emmanuel Tannenbaum
Feb 9, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Emmanuel TannenbaumEugene I Shakhnovich
Aug 16, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Emmanuel Tannenbaum
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Bohyun Lee, Emmanuel Tannenbaum
Sep 28, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Eran Itan, Emmanuel Tannenbaum
May 21, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Yisroel Brumer, Eugene I Shakhnovich
May 21, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Emmanuel TannenbaumEugene I Shakhnovich
Mar 11, 2006·Journal of Theoretical Biology·Emmanuel TannenbaumEugene I Shakhnovich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Emmanuel Tannenbaum, Eugene I Shakhnovich
Journal of Theoretical Biology
Emmanuel TannenbaumEugene I Shakhnovich
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Emmanuel Tannenbaum, Eugene I Shakhnovich
Physical Review Letters
Emmanuel TannenbaumEugene I Shakhnovich
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Yisroel Brumer, Eugene I Shakhnovich
© 2022 Meta ULC. All rights reserved