Semiflexible amphiphilic polymers: cylindrical-shaped, collagenlike, and toroidal structures

The Journal of Chemical Physics
Valentina V VasilevskayaA R Khokhlov

Abstract

A coarse-grained model is used to study the conformational properties of semiflexible polymers with amphiphilic monomer units containing both hydrophilic and hydrophobic interaction sites. The hydrophobically driven conformational transitions are studied using molecular dynamics simulations for the chains of varying stiffness, as characterized by intrinsic Kuhn segment lengths that vary over a decade. It is shown that the energy of hydrophobic attraction required for the realization of the coil-to-globule transition increases with increasing chain stiffness. For rather stiff backbone, the coil-to-globule transition corresponds to a first order phase transition. We find that depending on the chain stiffness, a variety of thermodynamically stable anisometric chain morphologies are possible in a solvent selectively poor for hydrophobic sites of amphiphilic monomer units. For flexible chains, the amphiphilic polymer forms a cylindrical globule having blob structure with nearly spherical blobs. With increasing stiffness, the number of blobs composing the globule decreases and the shape of blobs transforms into elongated cylinder. Further increase in stiffness leads to compaction of macromolecules into a collagenlike structure when t...Continue Reading

References

Jan 29, 1976·Nature·L C Gosule, J A Schellman
Feb 1, 1992·Protein Science : a Publication of the Protein Society·L Wesson, D Eisenberg
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K F Lau, K A Dill
Aug 1, 1986·Journal of Biomolecular Structure & Dynamics·K A Marx, G C Ruben
Jun 15, 1972·FEBS Letters·Y M EvdokimovY M Varshavsky
Feb 14, 1967·Journal of Molecular Biology·S M KlimenkoV M Andreev
Jan 1, 1995·Biophysical Journal·J Ubbink, T Odijk
Jun 1, 1996·Current Opinion in Structural Biology·V A Bloomfield
Nov 5, 1997·Cell·M E CerritelliA C Steven
Apr 16, 1998·Current Biology : CB·M M Hingorani, M O'Donnell
Apr 15, 1996·Physical Review Letters·K YoshikawaA R Khokhlov
Feb 13, 2001·Biophysical Journal·M J Stevens
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M M Hingorani, M O'Donnell
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·N V Hud, K H Downing
Jun 6, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Pavel G KhalaturAlexei R Khokhlov
Jul 28, 2004·The European Physical Journal. E, Soft Matter·A Goldar, J-L Sikorav

❮ Previous
Next ❯

Citations

Sep 4, 2012·The Journal of Chemical Physics·M K GlagolevA R Khokhlov
May 17, 2015·The Journal of Chemical Physics·A A LazutinA R Khokhlov
Jul 3, 2016·The Journal of Chemical Physics·Sergey V ZablotskiyWolfgang Paul
Aug 22, 2016·The Journal of Chemical Physics·J P Mahalik, M Muthukumar
Sep 24, 2019·Physical Chemistry Chemical Physics : PCCP·Naveed AthirJunying Zhang

❮ Previous
Next ❯

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Related Papers

The Journal of Chemical Physics
E Yu KramarenkoA R Khokhlov
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Yuji HiguchiTakafumi Iwaki
Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Françoise LivolantDominique Durand
© 2022 Meta ULC. All rights reserved