PMID: 8659777Mar 1, 1996Paper

Semilinear canonical correlation applied to the measurement of the electroencephalographic effects of midazolam and flumazenil reversal

Anesthesiology
T W SchniderS L Shafer

Abstract

The electroencephalographic (EEG) effect of benzodiazepines, and midazolam in particular, has been described using simple measures such as total power in the beta band, waves.s(-1) in the beta band and total power from aperiodic analysis. All these parameters failed to consistently describe the EEG effect of midazolam in a study in which large doses of midazolam were infused, and the effect subsequently reversed with flumazenil. Using a technique called semilinear correlation it is possible to extract a parameter from the EEG that is statistically optimally correlated with the apparent concentration of the benzodiazepine in the effect site. This method has been used to develop new univariate measures of the effects of opioids on the EEG but has not previously been applied to the EEG effects of benzodiazepines. Data from ten subjects who received an infusion of midazolam were analyzed. The data were divided into "learning" and "test" sets. The learning set consisted of ten studies in which the volunteers received an infusion of 2.5 mg.min(-1) midazolam. Semilinear canonical correlation was used to extract an univariate descriptor of the EEG effect by weighting the different frequency bands of the EEG power spectrum. The test set...Continue Reading

References

Nov 1, 1978·British Journal of Anaesthesia·C J HullM J Watson
Mar 1, 1979·Clinical Pharmacology and Therapeutics·L B SheinerJ Ham
Dec 1, 1992·Journal of Pharmacokinetics and Biopharmaceutics·K M GreggS L Shafer
Apr 1, 1989·Clinical Pharmacology and Therapeutics·D J GreenblattR I Shader
Sep 1, 1985·Journal of Clinical Pharmacology·U KlotzI W Reimann
Oct 1, 1984·British Journal of Clinical Pharmacology·I GathH Hadad

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Citations

Jun 9, 1999·Anesthesiology·T W SchniderE J Youngs
Jan 23, 2016·Anesthesia and Analgesia·Maxime Cannesson, Steven L Shafer
Nov 29, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masaaki NishidaEishi Asano
Jan 9, 2021·Journal of Pharmacokinetics and Pharmacodynamics·Kyung Mi KimJi-Yeon Bang
Jan 5, 2002·Annales Françaises D'anesthèsie Et De Rèanimation·V Billard, I Constant

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