Seminal plasma metabolites mediate the associations of multiple environmental pollutants with semen quality in Chinese men

Environment International
Qingyu HuangHeqing Shen

Abstract

Environmental exposure to arsenic, phthalate esters (PAEs) and perfluorinated compounds (PFCs) has been associated with human semen quality. However, the epidemiological "black-box" of these associations remains poorly uncovered. In this study, based on the association analysis between arsenic, PAE and PFC exposure and semen quality parameters (i.e., semen volume, sperm concentration, sperm count, progressive motility, total motility and normal morphology) in a Chinese male population, we explored the seminal plasma metabolic signatures that may mediate the exposure-outcome relations by using the meet-in-metabolite-analysis (MIMA) approach. As a result, a negative association was found between DMA and sperm concentration, whereas MEHP and PFHxS were positively associated with sperm count and concentration, respectively. Metabolomics analysis revealed that sixteen and twenty-two seminal plasma metabolites were related to sperm concentration and count, respectively, and they are mainly involved in fatty acid, lipid and amino acid metabolism. Moreover, it was further indicated that eicosatetraenoate, carnitines and DHA may impact the inverse association between DMA and sperm concentration, while eicosatetraenoate, carnitines, DHA,...Continue Reading

Citations

Jul 1, 2020·Andrologia·Manesh Kumar Panner SelvamRalf Henkel
Aug 4, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Kajsa Ugelvig PetersenSandra Søgaard Tøttenborg
Nov 6, 2020·Cell and Tissue Research·Bala Krishnan BinsilaRaghavendra Bhatta
Aug 1, 2021·Molecular Diagnosis & Therapy·Jesús García-FoncillasMaría Vanessa Pérez Gómez

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