Seminal plasma modulates the immune-cytokine network in the porcine uterine tissue and pre-ovulatory follicles

PloS One
Dagmar WaberskiRonald H F Hunter

Abstract

Evidence is emerging that the interaction between male seminal fluid and female tissues promotes fertility, pregnancy, and health of offspring. This includes the acceleration of ovulation in a species known as a spontaneous ovulator, the domestic pig. Earlier studies revealed that seminal plasma acts by a local mechanism in the female pig. The aim of the present study was to examine local short-term and mid-term effects of seminal plasma (SP) on mRNA expression of immunoregulatory genes and transcripts associated with follicle- and oocyte maturation. In the porcine animal model, effects on mRNA expression in the female tract and preovulatory follicles were examined. SP suppressed mRNA expression of Prostaglandin-Endoperoxide Synthase 2 (PTGS2) ipsilateral to the infused uterine horn which was associated with a lower presence of immune cells in the uterine epithelium and lower PTGS2 immunoreaction. Depending on the sampling time (2 h vs. 17 h) and hormonal status, SP altered significant correlative relations of mRNA expression between PTGS2 and the transcripts Tumor Necrosis Factor Alpha, Tumor Necrosis Factor Alpha-Induced Protein 6 and Pentraxin 3 in uterus, granulosa and cumulus cells. A modulatory effect of SP on the oocyte ...Continue Reading

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Citations

Jan 31, 2020·Physiological Reviews·John E Schjenken, Sarah A Robertson
Mar 12, 2020·International Journal of Molecular Sciences·Cristina A MartinezHeriberto Rodriguez-Martinez
May 28, 2020·International Journal of Molecular Sciences·Cristina A MartinezEmilio A Martinez
Oct 9, 2020·Animal Reproduction·Inmaculada ParrillaCristina Alicia Martinez
Nov 8, 2020·Animals : an Open Access Journal From MDPI·Inmaculada ParrillaEmilio A Martinez
May 1, 2021·International Journal of Molecular Sciences·Heriberto Rodriguez-MartinezJordi Roca
May 31, 2021·Journal of Reproductive Immunology·Seyed Omidreza MousaviReza Aflatoonian

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Methods Mentioned

BETA
hysterectomy
light microscopy
Chips
Electrophoresis
PCR

Software Mentioned

Leica LMD
SAS

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