PMID: 11920524Mar 29, 2002Paper

Seminal vesicle involvement in patients with D1 disease predicts early prostate specific antigen recurrence and metastasis after radical prostatectomy and early androgen ablation

Cancer
Thomas E AhleringAlan C Weinberg

Abstract

Controversy persists regarding the management of patients who present with locally advanced metastatic prostate carcinoma. Although radical prostatectomy is not curative, there is growing evidence that survival may be prolonged when the surgery is combined with early androgen ablation. In the current study, the authors present data with which to evaluate and define factors for disease progression in patients undergoing radical prostatectomy with lymph node positive disease who are treated with early endocrine ablation. Data from 40 patients undergoing radical prostatectomy and early androgen ablation between 1987-1998, all of whom had lymph node positive disease, were analyzed. Age, preoperative prostate specific antigen (PSA) level, clinical and pathologic Gleason score, surgical margin, seminal vesicle involvement (SVI), and the number and percentage of involved positive lymph nodes were analyzed to predict PSA progression, metastasis, and death using univariate and multivariate statistical techniques. Univariate analysis identified only SVI as a statistically significant predictor of PSA progression and metastasis. Twenty-seven patients (67.5%) were found to have SVI. Multivariate analysis failed to identify other factors th...Continue Reading

References

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Citations

Apr 12, 2005·Archives of Biochemistry and Biophysics·Danielle L CruthirdsLee Ann MacMillan-Crow
Sep 20, 2006·Prostate Cancer and Prostatic Diseases·N QuatanH Pandha
Feb 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hammou OubrahimP Boon Chock
May 11, 2005·Clinical Prostate Cancer·D Bruce SodeeGeorge Bakale
Dec 2, 2006·European Urology·Jens-Uwe StolzenburgEvangelos N Liatsikos

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