PMID: 6537894Mar 1, 1984Paper

Seminoma in a 46,XX true hermaphrodite with positive H-Y antigen. A case report

Cancer
L S Nichter

Abstract

This case study represents the first report of a 46,XX phenotypic male true hermaphrodite with a pure seminoma. Serologic testing of tissue demonstrated the presence of the H-Y antigen. This finding supports the theory that the H-Y gene is essential for primary sex determination and raises the possibility that it may also be the specific factor responsible for malignant degeneration of dysgenetic gonads.

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Apr 1, 1987·Cancer Genetics and Cytogenetics·M S Verp, J L Simpson
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