Semiology of spontaneous generalized tonic-clonic seizures in the epileptic baboon

Epilepsia Open
Charles Ákos SzabóSreekanth Koneru

Abstract

The epileptic baboon provides an animal model for juvenile myoclonic epilepsy (JME), demonstrating spontaneous generalized tonic-clonic seizures (GTCS) in addition to generalized myoclonic, absence and multifocal seizures. While photoconvulsive responses have been described in this model, spontaneous GTCS have not been characterized. In this study, we characterized 46 seizures in 7 epileptic baboons (5 females, 12 ± 3 years old) by video recording. While housed in single cages, the baboons were monitored for a median of 2 (range 1-10) weeks, with high-resolution, infrared-capable camera systems. Each GTCS was evaluated for evidence of preconvulsive ictal symptoms, focal convulsive behaviors, duration of the preconvulsive and convulsive periods, postictal immobility, and recovery of an upright posture. The circadian pattern of GTCS was also for each baboon. More than half of GTCS occurred in sleep, beginning from an upright position in all but one tethered baboon. Focal semiological findings were noted in 19 (41%) GTCS, and these included preconvulsive focal ictal motor behaviors as well as lateralized motor activity during the convulsions. The convulsive portion lasted 47 ± 10 seconds, whereas the entire seizure lasted 54 ± 21 ...Continue Reading

References

Oct 1, 1979·Electroencephalography and Clinical Neurophysiology·B S MeldrumJ M Stutzmann
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Aug 1, 1980·Electroencephalography and Clinical Neurophysiology·C L EhlersE K Killam
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Apr 25, 2009·Epilepsia·C Akos SzabóJeff T Williams
Mar 19, 2013·Epilepsy Research·C Ákos SzabóJeff T Williams
Nov 1, 2013·ILAR Journal·Laura A CoxJohn L VandeBerg
Jan 24, 2018·Epilepsy & Behavior : E&B·Lin XuRong Xue
Sep 17, 2018·Lancet Neurology·Philippa J KarolyMark J Cook

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Citations

May 23, 2021·Epilepsy & Behavior : E&B·C Ákos Szabó, Felipe S Salinas

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Software Mentioned

SeizureTracker
NeuroVista

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