PMID: 9423253Jan 10, 1998Paper

Semiparametric regression analysis for recurrent event interval counts

Biometrics
J G StaniswalisJ Salch

Abstract

This paper deals with analysis of data from longitudinal studies where the rate of a recurrent event characterizing morbidity is the primary criterion for treatment evaluation. We consider clinical trials which require patients to visit their clinical center at successive scheduled times as part of follow-up. At each visit, the patient reports the number of events that occurred since the previous visit, or an examination reveals the number of accumulated events, such as skin cancers. The exact occurrence times of the events are unavailable and the actual patient visit times typically vary randomly about the scheduled follow-up times. Each patient's record thus consists of a sequence of clinic visit dates, event counts corresponding to the successive time intervals between clinic visits, and baseline covariates. We propose a semiparametric regression model, extending the fully parametric model of Thall (1988, Biometrics 44, 197-209), to estimate and test for covariate effects on the rate of events over time while also accounting for the possibly time-varying nature of the underlying event rate. Covariate effects enter the model parametrically, while the underlying time-varying event rate is modelled nonparametrically. The method...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.