Semiparametric regression models for a right-skewed outcome subject to pooling

American Journal of Epidemiology
Emily M MitchellEnrique F Schisterman

Abstract

Pooling specimens prior to performing laboratory assays has various benefits. Pooling can help to reduce cost, preserve irreplaceable specimens, meet minimal volume requirements for certain lab tests, and even reduce information loss when a limit of detection is present. Regardless of the motivation for pooling, appropriate analytical techniques must be applied in order to obtain valid inference from composite specimens. When biomarkers are treated as the outcome in a regression model, techniques applicable to individually measured specimens may not be valid when measurements are taken from pooled specimens, particularly when the biomarker is positive and right skewed. In this paper, we propose a novel semiparametric estimation method based on an adaptation of the quasi-likelihood approach that can be applied to a right-skewed outcome subject to pooling. We use simulation studies to compare this method with an existing estimation technique that provides valid estimates only when pools are formed from specimens with identical predictor values. Simulation results and analysis of a motivating example demonstrate that, when appropriate estimation techniques are applied to strategically formed pools, valid and efficient estimation o...Continue Reading

References

Jun 25, 2003·Annals of Epidemiology·Janet B Hardy
Mar 15, 2006·Biostatistics·Sunni L MumfordAiyi Liu
Sep 11, 2008·Paediatric and Perinatal Epidemiology·Enrique F Schisterman, Albert Vexler
Apr 3, 2009·The New England Journal of Medicine·Rengaswamy SankaranarayananKetayun A Dinshaw
Oct 11, 2011·Biometrics·Yaakov MalinovskyEnrique F Schisterman
Mar 15, 2012·Statistics in Medicine·Robert H LylesBhramar Mukherjee
Mar 23, 2012·Statistics in Medicine·Brian W WhitcombRobert H Lyles
Feb 14, 2014·Biometrics·Emily M MitchellEnrique F Schisterman
Sep 16, 2014·Statistics in Medicine·Emily M MitchellEnrique F Schisterman

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Citations

Aug 18, 2016·Statistics in Medicine·Emily M MitchellEnrique F Schisterman
Dec 10, 2019·Statistical Methods in Medical Research·Moritz Berger, Matthias Schmid
May 9, 2019·Computational and Mathematical Methods in Medicine·Wenjun XiongJuan Ding
Jan 1, 2020·Journal of Nonparametric Statistics·Dewei WangXianzheng Huang

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