Semipermanent filler treatment of HIV-positive patients with facial lipoatrophy: long-term follow-up evaluating MR imaging and quality of life

Aesthetic Surgery Journal
Leo van RozelaarRefaat B Karim

Abstract

Injectable fillers such as poly-L-lactic acid (PLLA) and calcium hydroxylapatite (CaHA) have shown promising results in the treatment of combination antiretroviral therapy (cART)-induced facial lipoatrophy (FLA). However, the effects of these substances on magnetic resonance imaging (MRI) have not yet been described. The authors analyze the association between the effects of treatment with semipermanent fillers on MRI and changes in quality of life (QOL). Eighty-two human immunodeficiency virus (HIV)-positive patients with cART-induced FLA (grades 2-4) were enrolled in this prospective study. A mean volume of 58.2 mL (range, 12-105 mL) of PLLA (n = 41 patients) and 9.1 mL (range, 3-23 mL) of CaHA (n = 41) was injected in multiple sessions. The MRI examinations were performed prior to treatment and again 12 months after. The self-reported severity of FLA as well as QOL was measured using questionnaires based on Short Form 36, Medical Outcomes Study HIV Health Survey, and Center for Epidemiologic Studies Depression Scale formats. Significant increases in total subcutaneous thickness (TST) of the injected regions could be identified on MRI in nearly all patients 1 year posttreatment. Patients reported that mental health and social...Continue Reading

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Citations

Apr 11, 2015·AIDS Research and Human Retroviruses·Eugenia NegredoBonaventura Clotet
Nov 14, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Dana J LinJonathan K Kazam
Mar 2, 2017·Journal of Cosmetic Dermatology·J A Kadouch
Nov 5, 2016·International Journal of Dermatology·Christina N KrausChristopher B Zachary
Jun 27, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ximena Wortsman
Nov 18, 2018·Journal of Cosmetic Dermatology·Dario BertossiPier Francesco Nocini
Dec 15, 2018·The Journal of Craniofacial Surgery·Byeong Woo LimIl Gyu Kang

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