PMID: 701087Jan 1, 1978Paper

Semiquantitative computerized image analysis of fetal hemoglobin distribution patterns in sickle cell anemia and its variants

Hemoglobin
T D MialeF S Rotolo

Abstract

Computerized, semiquantitative image analysis of 2913 erythrocytes from 29 young patients with sickle cell anemia and its variants was conducted utilizing a modified method for determination of fetal hemoglobin distribution by an acid elution procedure. Histograms of eight arbitrary levels of staining intensity, proportional to fetal hemoglobin levels, were analyzed in relationship to both computer-generated, mathematical parameters of erythrocytic shape abnormalities and clinical parameters of disease severity. Shifts in fetal hemoglobin distribution were observed in analysis of sequential specimens. An inverse correlation was observed between angularity of erythrocytes and their individual fetal hemoglobin content (p less than or equal to 0.05). A positive correlation was noted between growth percentiles and percentage erythrocyte ghosts by acid elution (p less than or equal to 0.01).

References

Apr 14, 1976·Biochimica Et Biophysica Acta·S C Bernstein, J E Bowman
Dec 2, 1972·Lancet·R P PerrineA May
Mar 1, 1974·American Journal of Clinical Pathology·R N Wrightstone, T H Huisman
Aug 1, 1972·Archives of Disease in Childhood·M T AshcroftP Desai
Mar 1, 1969·Clinical Obstetrics and Gynecology·A L Chernoff, B F Horton
Dec 1, 1969·British Journal of Haematology·G R SerjeantP F Milner
Jun 15, 1957·Klinische Wochenschrift·E KLEIHAUERK BETKE

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Citations

Jul 1, 1980·British Journal of Haematology·W G WoodD J Weatherall

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