PMID: 7372553Jan 1, 1980Paper

Semisynthetic cephalosporins. III. Synthesis and structure activity relationships of novel orally active 7-[4-hydroxy-3-(substituted methyl)phenyl]-acetamido-3-cephem-4-carboxylic acids

The Journal of Antibiotics
A NudelmanR C Erickson

Abstract

A family of novel optically active alpha-amino-3-substituted-methyl-4-hydroxy benzene acetic acids (3) have been prepared. A number of these amino acids were converted to a group of cephalosporins (12). Compound 12A showed the most interesting activity in vitro and in vivo, primarily against Gram-positive organisms and was shown to be well absorbed orally.

Citations

Apr 1, 1990·Archiv der Pharmazie·S Berger, A Nudelman

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