Semisynthetic studies on the manzamine alkaloids

Journal of Natural Products
Khalid A El SayedMark T Hamann

Abstract

Chemical transformation studies were conducted on (-)-8-hydroxymanzamine A ( 1), (-)-manzamine F ( 2), manzamine A ( 3), and (+)-8-hydroxymanzamine A ( 4), isolated from Indo-Pacific Acanthostrongylophora sponges. Thirteen new semisynthetic manzamine derivatives, including four Delta (34,35) manzamines ( 5, 6, 8, and 9) and the unprecedented manzamine derivative 17, are reported. The potent in vitro activities of the obtained semisynthetic manzamines against activated brain microglia and the AIDS opportunistic infection pathogen Mycobacterium tuberculosis are presented.

References

Jul 18, 2001·Journal of the American Chemical Society·K A El SayedM T Hamann
Oct 30, 2003·Journal of the American Chemical Society·Jiangnan PengMark T Hamann
Nov 5, 2003·The Alkaloids. Chemistry and Biology·Jin-Feng HuMichelle Kelly
Jan 1, 1998·Journal of the American Chemical Society·Jeffrey D Winkler, Jeffrey M Axten

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Citations

Apr 10, 2012·The Journal of Organic Chemistry·Amir E Wahba, Mark T Hamann
Oct 16, 2010·Marine Drugs·Amir E Wahba, Mark T Hamann
Feb 4, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Kalimuthu Senthilkumar, Se-Kwon Kim
Jan 28, 2012·European Journal of Medicinal Chemistry·Abraham GarcíaGildardo Rivera
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Federica ArioliMercedes Amat
Sep 15, 2010·Natural Product Reports·Minoru IshikuraTakumi Abe
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Manuel Jesús Chan-BacabBenjamín Otto Ortega-Morales

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