PMID: 41434May 1, 1979

Sendai virus multiplication in the presence of ceruloplasmin and homologous virus envelopes

Acta Virologica
E TomasN Cajal


Preincubation of Sendai virus with ceruloplasmin induced in chorioallantoic membrane (CAM) fragments the synthesis of a population with decreased infectivity and high haemagglutinating (HA) and neuraminidase (NA) activities, whereas preincubation with solubilized virus envelopes led to the production of a viral population with the same infectivity as the control, but with lower HA and NA activities. Preincubation of the virus with a mixture of ceruloplasmin and solubilized envelopes depressed the overall virus synthesis; the resulting population had a low infectivity and high HA and NA activities. The variation in the HA/NA ratio indicates a modification in the envelope structure.

Related Concepts

Hemagglutinins, Viral
Viral Proteins
Virus Replication
Culture Techniques
Ferroxidase I
Chick Embryo
Extraembryonic Membranes
Para-Influenza Virus Type 1

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