Senescence and cell death pathways and their role in cancer therapeutic outcome

Current Medicinal Chemistry
M V ChiantoreG Romeo

Abstract

Anticancer drug-induced tumor suppression may involve mechanisms of protection against neoplastic transformation that are normally latent in mammalian cells and consist in a genetic program implemented during anti-tumoral defense. This defense program results in the self elimination of cells harboring potentially dangerous mutations by triggering cell death through apoptosis and/or autophagy or in the execution of a program that leads to a permanent growth arrest known as senescence. These responses are considered crucial tumor suppressive mechanisms and their study appears to be essential to develop therapeutical procedures based on the enhancement of the different responses. This review summarizes fundamental knowledge on the underlying mechanisms able to limit excessive or aberrant cellular proliferation and on the prognostic value of both apoptosis and senescence detection. In addition, interesting evidence showing that different drugs induce senescence or cell death depending on the genetic features of the tumor cells as well as on the integrity of the relative pathways is reported.

Citations

Dec 29, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhicai ZhangWeiwei Xu
Jul 31, 2013·Chinese Journal of Integrative Medicine·Hong-Yan TianZhao-Hua Dou
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ellen L GoodeLynn C Hartmann
Jun 17, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Bing HuQin DU
Dec 7, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong-Mei AnBing Hu
Jun 26, 2013·Proteomics·Mingxi LiNeil L Kelleher
Oct 26, 2010·Biochimica Et Biophysica Acta·Liam PorttMichael T Greenwood
May 14, 2016·Cellular Immunology·Radu Tudor CiorneiHelen Braley-Mullen

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