Senescence gives insights into the morphogenetic evolution of anamniotes

Biology Open
Éric VilliardStéphane Roy

Abstract

Senescence represents a mechanism to avoid undesired cell proliferation that plays a role in tumor suppression, wound healing and embryonic development. In order to gain insight on the evolution of senescence, we looked at its presence in developing axolotls (urodele amphibians) and in zebrafish (teleost fish), which are both anamniotes. Our data indicate that cellular senescence is present in various developing structures in axolotls (pronephros, olfactory epithelium of nerve fascicles, lateral organs, gums) and in zebrafish (epithelium of the yolk sac and in the lower part of the gut). Senescence was particularly associated with transient structures (pronephros in axolotls and yolk sac in zebrafish) suggesting that it may play a role in the elimination of these tissues. Our data supports the notion that cellular senescence evolved early in vertebrate evolution to influence embryonic development.

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Citations

Jun 22, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·José Antonio de Mera-RodríguezJavier Francisco-Morcillo
Oct 3, 2019·Development·Muriel RhinnWilliam M Keyes
Nov 2, 2019·Aging Cell·Sabela Da Silva-ÁlvarezManuel Collado
Jun 13, 2020·Frontiers in Pharmacology·Marie Helena DochertyDavid A Ferenbach
Apr 13, 2019·Scientific Reports·Alejandro GibajaMarta Magariños
Sep 30, 2020·Aging·Sabela Da Silva-ÁlvarezManuel Collado
Dec 10, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ulises Omar García-LepeRosa María Bermúdez-Cruz
Dec 15, 2020·Mechanisms of Ageing and Development·Melanie EnglerIon Cristian Cirstea
Feb 5, 2021·Frontiers in Cell and Developmental Biology·Emma WannerKarl Riabowol
Feb 16, 2021·Frontiers in Cell and Developmental Biology·José Antonio de Mera-RodríguezJavier Francisco-Morcillo
Nov 11, 2021·ELife·Diogo Paramos-de-CarvalhoLeonor Saúde

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