Senescence-Inflammatory Regulation of Reparative Cellular Reprogramming in Aging and Cancer

Frontiers in Cell and Developmental Biology
Javier A Menendez, Tomás Alarcón

Abstract

The inability of adult tissues to transitorily generate cells with functional stem cell-like properties is a major obstacle to tissue self-repair. Nuclear reprogramming-like phenomena that induce a transient acquisition of epigenetic plasticity and phenotype malleability may constitute a reparative route through which human tissues respond to injury, stress, and disease. However, tissue rejuvenation should involve not only the transient epigenetic reprogramming of differentiated cells, but also the committed re-acquisition of the original or alternative committed cell fate. Chronic or unrestrained epigenetic plasticity would drive aging phenotypes by impairing the repair or the replacement of damaged cells; such uncontrolled phenomena of in vivo reprogramming might also generate cancer-like cellular states. We herein propose that the ability of senescence-associated inflammatory signaling to regulate in vivo reprogramming cycles of tissue repair outlines a threshold model of aging and cancer. The degree of senescence/inflammation-associated deviation from the homeostatic state may delineate a type of thresholding algorithm distinguishing beneficial from deleterious effects of in vivo reprogramming. First, transient activation o...Continue Reading

References

Aug 1, 1991·Fertility and Sterility·M ZoltiR N Apte
Aug 3, 2002·Nature Reviews. Molecular Cell Biology·Jeremy P Brockes, Anoop Kumar
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Dec 22, 2004·Mechanisms of Ageing and Development·Judith Campisi
Jun 3, 2008·Nature Cell Biology·Darren J BakerJan M van Deursen
Jul 25, 2008·Nature·Ruslan Medzhitov
Aug 30, 2008·Cell·Valery KrizhanovskyScott W Lowe
Dec 5, 2008·Nature Reviews. Cancer·Seth Rakoff-Nahoum, Ruslan Medzhitov
Jan 10, 2009·Nature Reviews. Cancer·Thomas Kuilman, Daniel S Peeper
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
Jan 1, 2008·Cold Spring Harbor Symposia on Quantitative Biology·Nick BarkerHans Clevers
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Arturo V OrjaloJudith Campisi
Feb 4, 2010·Acta Neuropathologica·Fonnet E BleekerCornelis J F Van Noorden
Jan 1, 2006·Hereditary Cancer in Clinical Practice·Cjm LipsFl Moll
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
May 26, 2010·Journal of Clinical Pathology·Runjan Chetty
Nov 5, 2010·Cold Spring Harbor Symposia on Quantitative Biology·Vincent PasqueJ B Gurdon
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dimitrios IliopoulosKevin Struhl
Jan 18, 2011·Trends in Cell Biology·Kaoru SugimotoElliot M Meyerowitz
Jan 22, 2011·Nature Reviews. Molecular Cell Biology·Chris JoplingJuan Carlos Izpisua Belmonte
Feb 8, 2011·Biochimica Et Biophysica Acta·Jürgen SchellerStefan Rose-John
Feb 16, 2011·The Journal of Cell Biology·Francis Rodier, Judith Campisi
Apr 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christine L ChafferRobert A Weinberg
Jun 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hasan KorkayaMax S Wicha
Jul 21, 2011·Nature Immunology·Yinon Ben-Neriah, Michael Karin
Aug 27, 2011·Breast Cancer Research : BCR·Kateryna Shostak, Alain Chariot
Sep 3, 2011·Immunological Reviews·Petr Broz, Denise M Monack
Sep 24, 2011·Trends in Genetics : TIG·Vincent PasqueJ B Gurdon
Sep 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Siobhán Q GreggLaura J Niedernhofer
Jan 3, 2012·Seminars in Cancer Biology·Frances R Balkwill, Alberto Mantovani
Feb 3, 2012·Cold Spring Harbor Perspectives in Biology·Kim Newton, Vishva M Dixit
Mar 6, 2012·Nature·Tamer T OnderGeorge Q Daley
Jun 19, 2012·The Journal of Clinical Investigation·Jeremy S TilstraPaul D Robbins
Aug 16, 2012·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Andrew T Chan, Elmar Detering
Sep 25, 2012·Current Opinion in Cell Biology·Guang-Hui LiuJuan Carlos Izpisua Belmonte
Sep 25, 2012·Nature Cell Biology·Johan H van EsHans Clevers
Nov 13, 2012·Annual Review of Physiology·Judith Campisi
Dec 4, 2012·Nature Methods·Leo KurianJuan Carlos Izpisua Belmonte
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Heather A HirschKevin Struhl
Mar 5, 2013·The Journal of Clinical Investigation·Tamara TchkoniaJames L Kirkland
Mar 7, 2013·Nature Structural & Molecular Biology·Irene Cantone, Amanda G Fisher
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Somdutta RoyThea D Tlsty
Mar 28, 2013·Current Neurology and Neuroscience Reports·Adam L CohenHoward Colman
Mar 30, 2013·Science·Mario L SuvàBradley E Bernstein
Apr 25, 2013·Advances in Immunology·Evelyn Dixit, Jonathan C Kagan
May 28, 2013·Cancer Cell·Eric LetouzéJudith Favier
Jun 15, 2013·Cancer Cell·Ming Yang, Patrick J Pollard
Jun 19, 2013·Nature Cell Biology·Juan Carlos AcostaJesús Gil
Jul 31, 2013·Cancer Cell·Ariel PribludaYinon Ben-Neriah
Sep 21, 2013·Nature·Yoach RaisJacob H Hanna
Nov 8, 2013·Nature·Tushar J Desai, Mark A Krasnow
Nov 8, 2013·Nature·Purushothama Rao TataJayaraj Rajagopal
Nov 19, 2013·Cell·Daniel Muñoz-EspínManuel Serrano
Dec 7, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Evrim GurpinarGary A Piazza
Feb 7, 2014·The EMBO Journal·Haruhisa InoueShinya Yamanaka
Feb 13, 2014·Pharmacology & Therapeutics·Michela TerlizziRosalinda Sorrentino
Feb 18, 2014·EMBO Reports·Dinorah Friedmann-Morvinski, Inder M Verma
Mar 13, 2014·Cell Stem Cell·Robin M Hobbs, Jose M Polo
Apr 29, 2014·Molecular Cell·Raj Chovatiya, Ruslan Medzhitov
May 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Claudio Franceschi, Judith Campisi
Jun 17, 2014·Oncogene·P-Y Tung, P S Knoepfler
Jun 24, 2014·Nature Reviews. Molecular Cell Biology·Daniel Muñoz-Espín, Manuel Serrano
Jun 28, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Samantha A StreicherHarvey A Risch
Jul 16, 2014·Biochemical and Biophysical Research Communications·Kotaro OhnishiYasuhiro Yamada
Jul 18, 2014·Nature Reviews. Cancer·Colin R GodingXin Lu
Jul 30, 2014·Nature Reviews. Genetics·Jared L SterneckertHans R Schöler
Oct 18, 2014·Frontiers in Oncology·Javier A Menendez, Tomás Alarcón
Dec 3, 2014·Experimental Gerontology·James L Kirkland, Tamara Tchkonia
Dec 3, 2014·Current Opinion in Genetics & Development·John P CookeWing Tak Wong
Dec 17, 2014·Developmental Cell·Marco DemariaJudith Campisi
Jan 8, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Te-Sheng ChangYen-Hua Huang
Jan 27, 2015·Trends in Immunology·Jan MauerJens C Brüning
Jan 27, 2015·Oncoscience·Javier A MenendezTomás Alarcón
Feb 5, 2015·Archives of Pharmacal Research·Go Woon KimSung Hyun Chung
Feb 14, 2015·International Journal of Medical Sciences·Lilia DimitrovJohn D Heiss
Feb 24, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Harit KapoorSumeet K Mittal
Mar 25, 2015·Trends in Immunology·Audrey Lasry, Yinon Ben-Neriah
Apr 22, 2015·Nature Immunology·Christopher A Hunter, Simon A Jones
Jul 19, 2015·Journal of Leukocyte Biology·Ruth R Montgomery, Albert C Shaw
Jul 28, 2015·Nature Cell Biology·Clara Soria-VallesCarlos López-Otín
Sep 5, 2015·Cell Stem Cell·Michael D BrooksMax S Wicha
Sep 17, 2015·Cell Cycle·Clara Soria-VallesCarlos López-Otín
Sep 30, 2015·Developmental Cell·Kristjan R JessenPeter Arthur-Farraj
Dec 22, 2015·Cell Metabolism·Christopher D WileyJudith Campisi
Jan 23, 2016·Nature·Michael Karin, Hans Clevers
Jan 29, 2016·Nature Reviews. Molecular Cell Biology·Yishai AviorNissim Benvenisty
Feb 4, 2016·Nature·Darren J BakerJan M van Deursen
Feb 16, 2016·Stem Cell Reports·Javier A MenendezTomás Alarcón
Apr 7, 2016·Nature Communications·Reut YosefValery Krizhanovsky
Jul 9, 2016·Genome Biology·Dvir AranYinon Ben-Neriah
Aug 31, 2016·Advances in Experimental Medicine and Biology·David H Wang, Rhonda F Souza
Oct 11, 2016·Mechanisms of Ageing and Development·Clara Soria-VallesCarlos López-Otín
Dec 15, 2016·Frontiers in Immunology·Tomomi ToubaiPavan Reddy
Dec 17, 2016·Cancer Discovery·Marco DemariaJudith Campisi
Dec 17, 2016·Cell·Salah Mahmoudi, Anne Brunet
Dec 17, 2016·Cell·Alejandro OcampoJuan Carlos Izpisua Belmonte
Dec 27, 2016·Cell Stem Cell·Aurélie ChicheHan Li
Jan 4, 2017·Trends in Molecular Medicine·Peter L J de Keizer
Jan 17, 2017·Molecular & Cellular Oncology·Javier A Menendez, Tomás Alarcón
Feb 7, 2017·Stem Cell Reports·Rosa M MariónMaria A Blasco

Citations

Mar 16, 2018·PLoS Computational Biology·Núria Folguera-BlascoTomás Alarcón
Oct 3, 2017·Aging and Disease·William C Cho
Jun 12, 2018·Cell Cycle·Elisabet CuyàsJavier A Menendez
May 1, 2019·PLoS Computational Biology·Núria Folguera-BlascoTomás Alarcón
Aug 25, 2019·Aging·Javier A MenendezTomás Alarcón
May 15, 2018·Frontiers in Cardiovascular Medicine·Fabiana Passaro, Gianluca Testa

Methods Mentioned

BETA
environmental stresses

Related Concepts

Aging
Malignant Neoplasms
Cell Differentiation Process
Chronic Disease
Inflammation
Interleukin-6
Neuronal Plasticity
Self Administration
Signal Pathways
NF-kappa B

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