Senescence marker protein-30 knockout mouse as an aging model

Annals of the New York Academy of Sciences
Naoki MaruyamaYasushi Kasahara

Abstract

A mouse strain lacking SMP30 can be regarded as a strain showing ultimate decrease of the SMP30 molecule. After three months of age, SMP30-KO mice had an increased mortality rate, compared with the SMP30-WT mice, all of which remained alive. Electron microscopic observation of the hepatocytes from 12-month-old SMP30-KO mice revealed many empty vacuoles, presumably lipid droplets, abnormally enlarged mitochondria with indistinct cristae, and exceptionally large lysosomes filled with electron-dense bodies. The total hepatic triglyceride concentration of SMP30-KO mice was approximately 3.6-fold higher than that of the age-matched wild type. Similarly, the total hepatic cholesterol of SMP30-KO mice reached an approximate 3.3-fold greater value than that of the comparative group. Total hepatic phospholipids of SMP30-KO mice achieved an approximately 3.7-fold higher level compared with that of the wild-type mice. The cells from SMP30-KO mice were sensitive to apoptotic reagents. Those results supported the idea that SMP30 has an antiapoptotic function with wide spectrum. These findings indicate that SMP30-KO mice are highly susceptible to various harmful reagents. This strain might be a useful tool for aging and biological monitoring.

References

Jan 1, 1989·Experimental Gerontology·W YumuraN Maruyama
Oct 1, 1998·Biochemical and Biophysical Research Communications·T FujitaN Maruyama
Sep 25, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·Q HuangK T Blanchard

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Citations

Dec 4, 2009·Molecular & Cellular Proteomics : MCP·Chunxuan ShaoJun Yan
Nov 29, 2011·Molecular Human Reproduction·Sandra S LaurentinoSílvia Socorro
May 27, 2006·American Journal of Respiratory and Critical Care Medicine·Tadashi SatoAkihito Ishigami
Jan 5, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Akihito Ishigami
Oct 12, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Kazuhiro ItoNicolas Mercado
Oct 12, 2010·Digestive Diseases and Sciences·Susumu EguchiTakashi Kanematsu
Jan 13, 2009·Chest·Kazuhiro Ito, Peter J Barnes
Jan 20, 2015·Geriatrics & Gerontology International·Rei TakahashiKisaburo Nagata
Jul 22, 2008·Metabolism: Clinical and Experimental·Lihe ZhangH Henry Dong
Feb 28, 2006·Mechanisms of Ageing and Development·Tae Gen SonJaewon Lee
Dec 29, 2012·Journal of Veterinary Science·Min-A SeolSung-Kee Jo
Jul 31, 2012·Biomolecular Concepts·Stephanie H Scott, Brian J Bahnson

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