Senescence of staphylococci: using functional genomics to unravel the roles of ClpC ATPase during late stationary phase

International Journal of Medical Microbiology : IJMM
Indranil ChatterjeeMathias Herrmann

Abstract

Disease caused by Staphylococcus aureus frequently takes a chronic persistent course, and such infections are difficult to treat. S. aureus has developed various stress response systems allowing for coordinated expression of virulence factors and adaptation to environmental conditions. Clp ATPase/protease complexes for protein reactivation and degradation are highly conserved systems with a primary function in stress response. In various bacterial species, the role of Clp complexes has been associated with competence, cell wall synthesis, virulence and other physiologic properties. More recently, in S. aureus various Clp ATPases have been found to influence global regulator functions resulting in complex phenotypic changes. In this review, we briefly outline current knowledge including our own work with ClpC ATPase. We could highlight an important role of ClpC that allows for post-stationary regrowth and entry into the bacterial death phase through a functional tricarboxylic acid (TCA) cycle metabolism. We have concluded that ClpC may play a major regulatory role for long-term survival. Furthermore, using functional genomics data, we could extend the global characterization of the functions of ClpC in S. aureus with respect to ...Continue Reading

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Jun 22, 2005·Journal of Bacteriology·Indranil ChatterjeeMathias Herrmann
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Citations

Jan 20, 2011·Journal of General Internal Medicine·Jenna MartinGeraldine E Ménard
Jan 25, 2014·International Journal of Medical Microbiology : IJMM·Dorte FreesHanne Ingmer
Dec 21, 2012·Future Microbiology·Mathias HerrmannMartin P Grobusch
Jan 10, 2012·FEBS Letters·Antoine Danchin
Jan 5, 2016·International Journal of Medical Microbiology : IJMM·Kirsi SavijokiPekka Varmanen
Jan 29, 2011·International Journal of Medical Microbiology : IJMM·Indranil ChatterjeeSam Dukan
Mar 19, 2013·FEMS Microbiology Letters·Paula YagüeAngel Manteca
Nov 11, 2015·Scientific Reports·Shankar ThangamaniMohamed N Seleem

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