PMID: 11324654Apr 28, 2001Paper

Senescent expression of genes coding tropoelastin, elastase, lysyl oxidase, and tissue inhibitors of metalloproteinases in rat vocal folds: comparison with skin and lungs

Journal of Speech, Language, and Hearing Research : JSLHR
H Ding, S D Gray

Abstract

Histology studies indicate that vocal elastin content accumulates with age, suggesting possible contribution of elastin to age-associated voice changes. However, the underlying mechanism remains unclear. Using a reverse-transcriptase polymerase chain reaction (RT-PCR), mRNA levels of tropoelastin, elastase, lysyl oxidase, and tissue inhibitors of metalloproteinases (TIMP-1 to TIMP-4) were measured in vocal folds, tail skin, and lungs of rats at ages 1.5 +/- 0.5 weeks (neonatal), 6.0 +/- 0.5 months (adult), and 24 +/- 0.5 months (elderly). Vocal expression of both tropoelastin and lysyl oxidase peaks during the neonatal stage, followed by a significant decrease. Gene expression for elastase in the vocal folds of adult rats is not dissimilar to the neonatal levels. The levels in the elderly rots, however, show marked increase, to as much as 201% of the neonatal levels (p < .05). On the other hand, there is no conspicuous age-dependent variation in vocal expression of TIMPs. Gene expression of tropoelastin was similar in rat skin, lung, and vocal folds. In summary, compared to what is found in adult rats, there is a significant up-regulation in the expression of vocal elastase in the elderly animals in the presence of unchanged vo...Continue Reading

References

Dec 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R J KnudsonD E Knudson
Apr 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K ReiserR B Rucker
Aug 1, 1992·American Journal of Respiratory Cell and Molecular Biology·G Murphy, A J Docherty
Jan 1, 1972·The Anatomical Record·H D Bodley, R L Wood
May 1, 1982·The Journal of Investigative Dermatology·I M Braverman, E Fonferko
Nov 1, 1995·The Annals of Otology, Rhinology, and Laryngology·K Sato, M Hirano
Sep 1, 1996·Acta Oto-laryngologica·K IshiiH Hirose
Jan 1, 1997·The Annals of Otology, Rhinology, and Laryngology·K Sato, M Hirano

❮ Previous
Next ❯

Citations

May 8, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery·Katherine Kendall
Oct 1, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Markus GugatschkaGerhard Friedrich
Jun 29, 2011·Journal of Voice : Official Journal of the Voice Foundation·Jaime Moore, Susan Thibeault
Aug 9, 2005·Pathologie-biologie·Kornelia Molnarne SzauterKatalin Csiszar
May 7, 2002·The Annals of Otology, Rhinology, and Laryngology·Susan L ThibeaultR Kim Davis
Nov 10, 2009·The Annals of Otology, Rhinology, and Laryngology·Tsunehisa OhnoBernard Rousseau
Apr 21, 2009·The Annals of Otology, Rhinology, and Laryngology·Ryan C BranskiDiane Felsen
Apr 1, 2006·The Annals of Otology, Rhinology, and Laryngology·Mariah S HahnRobert Langer
Mar 7, 2006·The Annals of Otology, Rhinology, and Laryngology·Mariah S HahnRobert Langer
Apr 28, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael M JohnsFadi Ramadan
Feb 5, 2003·The Laryngoscope·Steven D GrayWenhua Li
Nov 11, 2008·Bioscience, Biotechnology, and Biochemistry·Yurika MizobeMitsuhiro Furuse
Jan 29, 2013·Drug Delivery and Translational Research·Balakrishnan SivaramanAnand Ramamurthi
Dec 18, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Edda SpiekerkoetterMarlene Rabinovitch
Aug 5, 2008·The Laryngoscope·Xia Chen, Susan L Thibeault
Jul 19, 2021·Matrix Biology : Journal of the International Society for Matrix Biology·Bo SunI-Cheng Ho

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Kiyoshi MakiyamaMomoka Nakai
© 2021 Meta ULC. All rights reserved