PMID: 11326427May 1, 2001Paper

Senile plaques in an aged western lowland gorilla

Experimental Animals
N KimuraY Yoshikawa

Abstract

Senile plaques (SPs) were found in the cerebral cortex of a 44-year-old Western lowland gorilla (Gorilla gorilla gorilla). All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red. More SPs were detected by immunostaining for amyloid beta protein (A beta) and a half of A beta-positive-SPs were also immunoreactive for apolipoprotein E. Moreover, all SPs were immunoreactive for A beta 42 and A beta 43, but not for A beta 40. SPs also did not contain A beta precursor protein-positive structures. These findings suggested that SPs in this case were diffuse plaques. To our knowledge, this is the first report of SPs in the gorilla.

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Citations

Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chet C SherwoodWilliam D Hopkins
Nov 5, 2013·Brain Structure & Function·Amy L BauernfeindChet C Sherwood
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Apr 17, 2019·International Journal of Molecular Sciences·Anita GołaszewskaArkadiusz Orzechowski
Dec 28, 2016·Acta Neuropathologica·Eleanor Drummond, Thomas Wisniewski
Oct 1, 2017·Clinical Science·Lieke JäkelMarcel M Verbeek
Jun 3, 2021·Cells·Melissa K EdlerJason R Richardson
Jul 14, 2021·American Journal of Primatology·Carmen Freire-CoboPatrick R Hof
Aug 28, 2021·International Journal of Molecular Sciences·Anaïs VignonJoan Torrent

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