Abstract
SUMO/sentrin specific protease 1 (Senp1) is an important regulation protease in the protein sumoylation, which affects the cell cycle, proliferation and differentiation. The role of Senp1 mediated protein desumoylation in pathophysiological progression of multiple myeloma is unknown. In this study, we demonstrated that Senp1 is overexpressed and induced by IL-6 in multiple myeloma cells. Lentivirus-mediated Senp1 knockdown triggers apoptosis and reduces viability, proliferation and colony forming ability of MM cells. The NF-κB family members including P65 and inhibitor protein IkBα play important roles in regulation of MM cell survival and proliferation. We further demonstrated that Senp1 inhibition decreased IL-6-induced P65 and IkBα phosphorylation, leading to inactivation of NF-кB signaling in MM cells. These results delineate a key role for Senp1in IL-6 induced proliferation and survival of MM cells, suggesting it may be a potential new therapeutic target in MM.
References
Feb 21, 2004·Immunity·Li Hua WangWilliam L Farrar
Mar 17, 2004·Oncogene·Jung-Hsin HsuAlan Lichtenstein
Jun 27, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kurt BommertThorsten Stühmer
May 15, 2007·Trends in Biochemical Sciences·Debaditya Mukhopadhyay, Mary Dasso
Aug 10, 2007·British Journal of Haematology·Qing-Fang LiLi-Sheng Wang
Oct 16, 2007·Nature Cell Biology·Yonghua YangWenlong Bai
Jul 31, 2008·IUBMB Life·Marcin Drag, Guy S Salvesen
Sep 19, 2008·The Journal of Biological Chemistry·Christopher D Lima, David Reverter
Nov 29, 2008·The Lancet Oncology·Enrique M OcioJesús F San-Miguel
Dec 1, 2009·Biotechnology Journal·Artemisia M Andreou, Nektarios Tavernarakis
Dec 3, 2010·Targeted Oncology·James J Driscoll, Roopa Dechowdhury
Jan 31, 2012·Molecular Cell·Thang Van NguyenEdward T H Yeh
Jun 27, 2012·Oncogene·Q WangJ Cheng
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Bin-Bin HuangAi-Bin Liang
Nov 24, 2012·Nature Reviews. Molecular Cell Biology·Christopher M HickeyMark Hochstrasser
Mar 22, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nikhil C Munshi, Kenneth C Anderson
Oct 19, 2013·Experimental and Therapeutic Medicine·Ruo-Tian WangJian Zhang
Oct 15, 2014·Cancer Cell·Laura TornatoreGuido Franzoso
Citations
Dec 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenwen ZhangLisheng Wang
Apr 26, 2016·Journal of Ophthalmology·Jian GaoXun Xu
Nov 4, 2016·Gene·Wenrong XiaDonggang Xu
Jan 31, 2017·Nature Reviews. Cancer·Jacob-Sebastian Seeler, Anne Dejean
Nov 24, 2016·Molecular Aspects of Medicine·James ChonMartha S Field
Oct 13, 2017·Hematology·Shuang LiuQing Zhang
Aug 11, 2017·Journal of Cellular Biochemistry·Xiaowei WangBing Wang
Jul 26, 2018·Journal of Clinical Laboratory Analysis·Keyuan LiuHao Wang
May 23, 2018·Molecular Pharmacology·Yanfang YangShufang Liang
Oct 16, 2016·Oncotarget·Baijun DongYiran Huang
Nov 9, 2016·The Journal of Experimental Medicine·Priti AzadGabriel G Haddad
Jan 23, 2020·Scientific Reports·Hongyi XiePeng Shu
Feb 28, 2018·International Journal of Oncology·Zhi-Jian HanHao Chen
Aug 14, 2019·International Journal of Molecular Sciences·Mathias BoulangerGuillaume Bossis
May 3, 2019·Acta Crystallographica. Section F, Structural Biology Communications·Nigus D Ambaye
Dec 30, 2020·Adipocyte·Yingying WuMin Wang
Feb 4, 2021·Journal of Biomolecular Structure & Dynamics·Somayye TaghvaeiAlireza Taghvaei
Dec 5, 2020·Stem Cells International·Qi ZhaoShiwu Zhang
Dec 18, 2020·Cancers·Matthias WirthJan Krönke
Apr 4, 2019·European Journal of Pharmacology·Xiaoyu GaoXiaoshan Feng
Mar 3, 2018·Molecular Cell·Maria Dafne CardamoneValentina Perissi
May 1, 2021·Cancers·Katie DunphyPeter O'Gorman
May 1, 2021·Cancers·Paulina Tokarz, Katarzyna Woźniak
Jul 28, 2021·Cell Death Discovery·Yali ZhangXi Li