Sense and sensitivity: FOXO and ROS in cancer development and treatment.

Antioxidants & Redox Signaling
S S MyattE W-F Lam

Abstract

Forkhead box O (FOXO) transcription factors are at the center of an emerging paradigm that links longevity, cell fate, and tumor development. Key to these processes is the ability of FOXO to regulate, and be regulated by, oxidative stress. Perturbation of the mechanisms that tightly couple reactive oxygen species (ROS) production, oxidative stress signaling, and FOXO activity to the subsequent cellular response is a pivotal step in cancer development and progression. Consequently, the ROS-FOXO pathway is a major therapeutic target in cancer, not only as it mediates the cellular response to chemotherapy, but also because it underpins drug resistance. As the intimate and reciprocal relation between FOXO and ROS is being unravelled, new opportunities arise to develop more-effective cancer treatments that circumvent resistance to the conventional cytotoxic drugs.

References

May 6, 1991·Biochimica Et Biophysica Acta·A R Cross, O T Jones
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·V GoossensW Fiers
Apr 1, 1993·Trends in Biochemical Sciences·E Nishida, Y Gotoh
Apr 26, 1996·The Journal of Biological Chemistry·Y XiaJ L Zweier
Mar 14, 1997·Science·K IraniP J Goldschmidt-Clermont
Sep 26, 1997·Nature·K PolyakB Vogelstein
Jan 24, 1998·The Journal of Biological Chemistry·H BaeS G Graber
Apr 17, 1999·Cellular Signalling·H Kamata, H Hirata
Feb 9, 2000·Journal of Bioenergetics and Biomembranes·J Cai, D P Jones
Feb 13, 2001·The Journal of Nutrition·L PackerG Rimbach
Sep 7, 2002·Antioxidants & Redox Signaling·Shugo UedaJunji Yodoi
Oct 7, 2003·The Journal of Biological Chemistry·Andrew SuntersEric W-F Lam
Nov 5, 2003·Medicinal Research Reviews·Stephan GromerKatja Becker
Jan 27, 2004·Nature Cell Biology·Salvatore PapaGuido Franzoso
May 12, 2004·Current Medicinal Chemistry·G PoliE Chiarpotto
Jun 11, 2004·Annual Review of Biochemistry·Gil Blander, Leonard Guarente
Oct 29, 2004·Molecular and Cellular Biology·Silvia Fernández de MattosEric W-F Lam
Nov 13, 2004·The EMBO Journal·Marieke A G EssersBoudewijn M T Burgering
Jan 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·John A PetrosDouglas C Wallace
Apr 6, 2005·Biochemistry. Biokhimii︠a︡·A Yu AndreyevA A Starkov
Apr 23, 2005·Journal of Natural Products·Frank C SchroederJon Clardy
May 21, 2005·Science·Marieke A G EssersHendrik C Korswagen
Jul 12, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J G Scandalios
Jul 13, 2005·The Journal of Cell Biology·Jun SunayamaYukiko Gotoh
Aug 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hitomi MatsuzakiAkiyoshi Fukamizu
Oct 19, 2005·Genes & Development·Oscar Puig, Robert Tjian
Dec 13, 2005·Journal of Medicinal Chemistry·Andrew D NapperRory Curtis

❮ Previous
Next ❯

Citations

Nov 14, 2012·Antioxidants & Redox Signaling·Matteo Parri, Paola Chiarugi
Feb 28, 2013·Science Signaling·Sehyun ChaeKyong Soo Park
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mohamed SaeedThomas Efferth
Feb 9, 2012·The Journal of Cell Biology·Inna V Nechipurenko, Heather T Broihier
Nov 13, 2015·In Vitro Cellular & Developmental Biology. Animal·Soraya SajadimajdFariba Roshanzamir
May 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chao ZhangYing-Feng Zhou
Jun 19, 2012·International Journal of Radiation Biology·Irena Szumiel
Oct 25, 2011·Free Radical Biology & Medicine·Beyza VurusanerHuveyda Basaga
Mar 16, 2017·CNS Neuroscience & Therapeutics·Wei YangDe-Ming Zhao
Nov 19, 2010·Antioxidants & Redox Signaling·Tobias B Dansen
Nov 30, 2018·PloS One·Laura De-UgarteNatalia Garcia-Giralt
May 7, 2020·Cancer Metastasis Reviews·Yannasittha Jiramongkol, Eric W-F Lam
Dec 1, 2011·The Journal of Biological Chemistry·Ka-Kei HoEric W-F Lam
Oct 9, 2020·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Pegah FarhadiKamran Mansouri
Oct 8, 2011·Molecular Cancer Therapeutics·Angela NebbiosoLucia Altucci

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
John P Fruehauf, Frank L Meyskens
Ageing Research Reviews
Venus SosaMatilde E LLeonart
© 2021 Meta ULC. All rights reserved