Sensing centromere tension: Aurora B and the regulation of kinetochore function

Trends in Cell Biology
Michael A Lampson, Iain M Cheeseman


Maintaining genome integrity during cell division requires regulated interactions between chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct chromosomes, the sister kinetochores must attach to opposite spindle poles. Tension across the centromere stabilizes correct attachments, whereas phosphorylation of kinetochore substrates by the conserved Ipl1/Aurora B kinase selectively eliminates incorrect attachments. Here, we review our current understanding of how mechanical forces acting on the kinetochore are linked to biochemical changes to control chromosome segregation. We discuss models for tension sensing and regulation of kinetochore function downstream of Aurora B, and mechanisms that specify Aurora B localization to the inner centromere and determine its interactions with substrates at distinct locations.


Jan 1, 1992·Cell Motility and the Cytoskeleton·J G Ault, C L Rieder
Sep 1, 1994·The Journal of Cell Biology·R B Nicklas, S C Ward
Jan 31, 1997·Science·R B Nicklas
Apr 12, 2003·Developmental Cell·Yukinori MinoshimaToshio Kitamura
Apr 30, 2003·The Journal of Cell Biology·Claire DitchfieldStephen S Taylor
Aug 20, 2003·Molecular Biology of the Cell·Reiko HondaErich A Nigg
Aug 20, 2003·Molecular Biology of the Cell·Ching ShangGeorjana Barnes
Jan 15, 2004·The Journal of Biological Chemistry·Yoshihiro YasuiMasaki Inagaki
Feb 10, 2004·Nature Cell Biology·Michael A LampsonTarun M Kapoor
Feb 13, 2004·Developmental Cell·Paul D AndrewsJason R Swedlow
Dec 14, 2004·Current Biology : CB·Daniela CiminiE D Salmon
Apr 28, 2005·Current Biology : CB·Annika GuseMichael Glotzer
May 4, 2005·Molecular Cell·Fabio SessaAndrea Musacchio
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bedrick B Gadea, Joan V Ruderman
Sep 5, 2006·Current Biology : CB·Anne Lide KnowltonP Todd Stukenberg
Nov 7, 2006·Developmental Cell·Jun DaiJonathan M G Higgins
Feb 16, 2007·Molecular Biology of the Cell·Vincent VanoosthuyseKevin G Hardwick
Feb 27, 2007·Genes & Development·Shigehiro A KawashimaYoshinori Watanabe
Apr 26, 2007·Cell Cycle·Sally P WheatleySusanne M A Lens
Apr 28, 2007·Annual Review of Biomedical Engineering·Paul A Janmey, Christopher A McCulloch
Aug 3, 2007·Cell Cycle·Marlène Delacour-LaroseAnnie Molla

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Feb 19, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Elina VladimirouAndrew D McAinsh
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lei Tan, Tarun M Kapoor
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