Sensing developing biofilms: the bitter receptor T2R38 on myeloid cells

Pathogens and Disease
Matthias Martin GaidaGertrud Maria Hänsch

Abstract

Quorum-sensing molecules, also known as autoinducer, are essential for bacterial biofilm formation. Our focus is on N-(3-oxododecanoyl)-L-homoserine lactone (AHL-12), because it is also known as an 'interkingdom signalling molecule', which means that it also interacts with mammalian cells. AHL-12 activates defence-relevant functions of phagocytic cells, including enhancement of phagocytosis, increased expression of adhesion receptors and induction of chemotaxis. This leads to the hypothesis that early recognition of developing biofilms might be the key to a successful host defence against biofilm infection. In that context we studied activation of phagocytic cells by AHL-12, and found that phagocytes are activated via a rather specialized receptor that was not previously described on myeloid cells, the bitter taste receptor T2R38. Taste receptors are commonly associated with cells of the gustatory system. The extragustatory expression, however, suggests an additional role, namely the sensing of the onset of bacterial biofilm infection.

References

May 21, 1999·Science·J W CostertonE P Greenberg
Apr 13, 2000·Cell·E AdlerC S Zuker
Jun 1, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·V Witko-SarsatL Halbwachs-Mecarelli
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·S Vincent WuEnrique Rozengurt
Sep 26, 2002·Expert Review of Molecular Diagnostics·Carla Renata ArciolaLucio Montanaro
Jul 21, 2005·Reviews of Physiology, Biochemistry and Pharmacology·Wolfgang Meyerhof
Oct 13, 2005·FEMS Microbiology Reviews·Erin K ShinerSimon C Williams
Sep 22, 2006·Infection and Immunity·Sabine ZimmermannGertrud Maria Hänsch
Dec 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hsiao-Ching WanPeter F Weller
Sep 4, 2007·Trends in Cell Biology·Michael A Welte
Dec 1, 2009·Cell·Robert V Farese, Tobias C Walther
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marco TizzanoThomas E Finger
Mar 23, 2010·FEBS Letters·Mathias BellerHerbert Jäckle
Apr 20, 2010·The Journal of Biological Chemistry·Venkata R NaralaRaju C Reddy
Jun 29, 2010·FEMS Immunology and Medical Microbiology·Peter Østrup JensenClaus Moser
Feb 10, 2011·Biochemical and Biophysical Research Communications·Nisha SinghPrashen Chelikani
May 20, 2011·The Biochemical Journal·Tae-Il JeonTimothy F Osborne
Jan 5, 2012·Journal of Leukocyte Biology·Gertrud M Hänsch
May 10, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Christoph BarthPatrick Koelsch
Jul 14, 2012·PloS One·Maik BehrensWolfgang Meyerhof
Oct 9, 2012·The Journal of Clinical Investigation·Robert J LeeNoam A Cohen
Feb 6, 2013·Gut Microbes·V K Viswanathan
May 21, 2013·Annual Review of Microbiology·Martin SchusterE Peter Greenberg
Mar 13, 2014·Biochemical and Biophysical Research Communications·Nisha SinghPrashen Chelikani
Jul 16, 2014·Frontiers in Plant Science·Angelika Holm, Elena Vikström

❮ Previous
Next ❯

Citations

Nov 8, 2016·Laryngoscope Investigative Otolaryngology·Ryan M CareyNoam A Cohen
Jul 19, 2017·American Journal of Rhinology & Allergy·Ryan M CareyNoam A Cohen
Jul 17, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Appalaraju JaggupilliPrashen Chelikani
Mar 21, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shèdy TaherKirk P Conrad
Sep 14, 2017·PloS One·Christophe VerbeurgtPierre Chatelain
Sep 6, 2019·Current Allergy and Asthma Reports·Ajay P NayakDeepak A Deshpande
Jan 6, 2017·The Journal of General Physiology·Ping LuRonghua ZhuGe
Aug 31, 2019·Nutrients·Ryan M Carey, Robert J Lee
Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ulrike DapuntJan Philippe Kretzer
Oct 22, 2019·Frontiers in Physiology·Stanislas Grassin-DelylePhilippe Devillier
May 28, 2020·Frontiers in Physiology·Conor J BloxhamWalter G Thomas
Jan 9, 2019·Frontiers in Immunology·Hoai T T TranEvelyn Lamy
Aug 6, 2019·Frontiers in Physiology·Ajay P NayakDeepak A Deshpande
Mar 17, 2020·Cellular and Molecular Life Sciences : CMLS·Indiwari GopallawaRobert J Lee
Oct 31, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Elizabeth A SellNoam A Cohen
Dec 17, 2020·Therapeutics and Clinical Risk Management·Ulrike DapuntYina Zhao
Mar 9, 2021·Drug Design, Development and Therapy·Weyland ChengFangna Liu
Nov 7, 2020·FEMS Microbiology Ecology·Abhishek Shrestha, Adam Schikora
Jun 30, 2021·Biochimie·Kristyna Krasulova, Peter Illes
Sep 7, 2021·Frontiers in Molecular Biosciences·Premnath DhanarajMosae Selvakumar Paulraj
Nov 15, 2018·Journal of Innate Immunity·Maria V Turkina, Elena Vikström

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
flow cytometry
FACS
pull-down
fluorescence microscopy
biopsies

Software Mentioned

CellQuest Pro

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.