Sensing membrane thickness: Lessons learned from cold stress

Biochimica Et Biophysica Acta
Emilio A SaitaDiego de Mendoza

Abstract

The lipid bilayer component of biological membranes is important for the distribution, organization, and function of bilayer spanning proteins. These physical barriers are subjected to bilayer perturbations. As a consequence, nature has evolved proteins that are able to sense changes in the bilayer properties and transform these lipid-mediated stimuli into intracellular signals. A structural feature that most signal-transducing membrane-embedded proteins have in common is one or more α-helices that traverse the lipid bilayer. Because of the interaction with the surrounding lipids, the organization of these transmembrane helices will be sensitive to membrane properties, like hydrophobic thickness. The helices may adapt to the lipids in different ways, which in turn can influence the structure and function of the intact membrane proteins. We review recent insights into the molecular basis of thermosensing via changes in membrane thickness and consider examples in which the hydrophobic matching can be demonstrated using reconstituted membrane systems. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon.

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Citations

May 18, 2016·Biochimica Et Biophysica Acta·Anant K Menon, Tim P Levine
Aug 16, 2016·Journal of Molecular Biology·Christopher P ZschiedrichHendrik Szurmant
Aug 19, 2016·Journal of Molecular Biology·Robert ErnstBruno Antonny
Jul 18, 2016·Biochimica Et Biophysica Acta·Maria A Sinetova, Dmitry A Los
Oct 22, 2016·Biochimica Et Biophysica Acta. General Subjects·Yuguang WangMichael R Hamblin
Mar 30, 2017·Biophysical Journal·Javier Iglesias-FernandezCarmen Domene
Jun 11, 2016·Biochemical Society Transactions·Mayuriben J ParmarVincent L G Postis
Oct 11, 2017·Journal of Experimental Botany·William J NicolasEmmanuelle M Bayer
Mar 30, 2018·Current Opinion in Structural Biology·Charles R Sanders, James M Hutchison
Oct 15, 2021·Environmental Science and Pollution Research International·Lijun ShenGuang Chen

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