Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity

Journal of Leukocyte Biology
José Carlos Santos, Petr Broz

Abstract

Guanylate-binding proteins (GBPs) are conserved family of IFN-inducible GTPases that play an important role in the host immunity against bacterial, viral, and protozoan pathogens. GBPs protect the host by associating with intracellular microbes, their vacuolar niche or, in the case of viruses, with their replication complex. This association results in a restriction of the respective pathogen, yet the exact molecular mechanisms of the antimicrobial functions of GBPs are still unclear. Recent work has linked the GBPs with the activation of inflammasomes, multi-protein complexes that assemble upon recognition of pathogen- or host-derived signals and that drive the release of cytokines and host cell death. Here, we will focus on the most recent findings that have started to unravel the manifold restriction mechanism controlled by GBPs in mouse and human cells, and that shed light on the molecular cues that control GBP recruitment to bacterial membranes.

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Citations

Jun 4, 2019·The EMBO Journal·Daniel FischEva-Maria Frickel
Apr 8, 2020·Infection and Immunity·Nicole P GiordanoZachary D Dalebroux
Sep 18, 2020·PLoS Pathogens·Omoshola Aleru, Matthew F Barber
Jan 23, 2020·MBio·Nora SteffensDaniel Degrandi
Jul 4, 2019·The EMBO Journal·Daniel FischEva-Maria Frickel
Jan 23, 2021·Nature Communications·David E PlaceThirumala-Devi Kanneganti
Jan 7, 2021·The FEBS Journal·Linda SistemichChristian Herrmann
Feb 23, 2020·Journal of Molecular Biology·Linda SistemichChristian Herrmann
Mar 7, 2021·Journal of Biomedical Science·Rongzhao ZhangChunfu Zheng
May 19, 2021·Biochemical Society Transactions·Heike L RafeldElizabeth L Hartland
Dec 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kaixin DingZheng Chen

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