Sensing of tubular flow and renal electrolyte transport.

Nature Reviews. Nephrology
Eric H J VerschurenJoost G J Hoenderop

Abstract

The kidney is a remarkable organ that accomplishes the challenge of removing waste from the body and simultaneously regulating electrolyte and water balance. Pro-urine flows through the nephron in a highly dynamic manner and adjustment of the reabsorption rates of water and ions to the variable tubular flow is required for electrolyte homeostasis. Renal epithelial cells sense the tubular flow by mechanosensation. Interest in this phenomenon has increased in the past decade since the acknowledgement of primary cilia as antennae that sense renal tubular flow. However, the significance of tubular flow sensing for electrolyte handling is largely unknown. Signal transduction pathways regulating flow-sensitive physiological responses involve calcium, purinergic and nitric oxide signalling, and are considered to have an important role in renal electrolyte handling. Given that mechanosensation of tubular flow is an integral role of the nephron, defective tubular flow sensing is probably involved in renal disease. Studies investigating tubular flow and electrolyte transport differ in their methodology, subsequently hampering translational validity. This Review provides the basis for understanding electrolyte disorders originating from a...Continue Reading

References

May 1, 1979·The American Journal of Physiology·T OhhashiM Sakaguchi
Jan 1, 1976·Annual Review of Physiology·B M BrennerC R Robertson
Apr 1, 1975·The American Journal of Physiology·R N KhuriG Giebisch
Apr 1, 1992·The Journal of Clinical Investigation·D A MaddoxF J Gennari
Jul 1, 1991·Kidney International·D G Shirley, S J Walter
May 1, 1989·The American Journal of Physiology·G MalnicG Giebisch
Jun 1, 1989·The American Journal of Physiology·N H Holstein-Rathlou, D J Marsh
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P F DaviesM A Gimbrone
Nov 1, 1986·Biophysical Journal·T SakaiD J Marsh
Sep 1, 1968·The Journal of Clinical Investigation·M B Burg, J Orloff
Sep 1, 1973·Kidney International·L G Wesson
Apr 1, 1974·The American Journal of Anatomy·R E BulgerR Pendergrass
Oct 12, 1965·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·A FrickW E Lassiter
Jan 1, 1970·Pflügers Archiv : European journal of physiology·J SchnermannG Grill
Mar 1, 1970·The Journal of Physiology·K Green, T Otori
Jul 1, 1981·Kidney International·L N Reinking, B Schmidt-Nielsen
Jan 1, 1996·The American Journal of Physiology·H P KosterR J Bindels
Jun 24, 1998·The Journal of Membrane Biology·J Taniguchi, M Imai
May 13, 1999·Biochimica Et Biophysica Acta·D J Stuehr
Jun 3, 2000·American Journal of Physiology. Renal Physiology·T H KwonS Nielsen
Jun 28, 2000·Journal of the Autonomic Nervous System·M A BaileyR J Unwin
Sep 21, 2000·American Journal of Physiology. Renal Physiology·P GuoS Weinbaum
Apr 9, 2001·American Journal of Physiology. Renal Physiology·C B WodaL M Satlin
May 16, 2001·American Journal of Physiology. Renal Physiology·L M SatlinT R Kleyman
Oct 11, 2001·American Journal of Physiology. Renal Physiology·L J DaiG A Quamme
Nov 1, 2001·The Journal of Membrane Biology·H A Praetorius, K R Spring
Mar 7, 2002·American Journal of Physiology. Renal Physiology·Erik M SchwiebertAmanda L Taylor
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Craig B WodaLisa M Satlin
Sep 5, 2002·Annual Review of Physiology·Jürgen Schnermann, David Z Levine
Sep 20, 2002·Journal of the American Society of Nephrology : JASN·Bradley K YoderLisa M Guay-Woodford
Jan 18, 2003·The Journal of Membrane Biology·H A Praetorius, K R Spring
May 23, 2003·Journal of the American Society of Nephrology : JASN·Marie Essig, Gérard Friedlander
Jun 18, 2003·Biochemical and Biophysical Research Communications·Troels WabakkenHans-Christian Aasheim
Jun 26, 2003·American Journal of Physiology. Renal Physiology·Craig B WodaLisa M Satlin
Jul 3, 2003·American Journal of Physiology. Renal Physiology·Wen LiuLisa M Satlin
Jul 19, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Volker Vallon
Aug 16, 2003·Current Opinion in Nephrology and Hypertension·Helle A Praetorius, Kenneth R Spring

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Citations

Sep 29, 2020·American Journal of Physiology. Renal Physiology·Dominique M BoveeEwout J Hoorn
Sep 10, 2020·Cellular and Molecular Bioengineering·Holly Ryan, Chelsey S Simmons
Oct 12, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dominique J McConnachieAndrew J Mallett
Feb 3, 2021·Micromachines·Leslie DonoghuePalaniappan Sethu
Mar 22, 2021·Pharmacology & Therapeutics·Dagmar Wachten, David U Mick
Sep 3, 2021·Journal of Cell Science·Aurore Claude-TaupinNicolas Dupont
Nov 9, 2021·Biochemical Society Transactions·Etienne MorelPatrice Codogno

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