Sensing parasites: Proteomic and advanced bio-detection alternatives

Journal of Proteomics
Carlos Sánchez-OvejeroRaúl Manzano-Román

Abstract

Parasitic diseases have a great impact in human and animal health. The gold standard for the diagnosis of the majority of parasitic infections is still conventional microscopy, which presents important limitations in terms of sensitivity and specificity and commonly requires highly trained technicians. More accurate molecular-based diagnostic tools are needed for the implementation of early detection, effective treatments and massive screenings with high-throughput capacities. In this respect, sensitive and affordable devices could greatly impact on sustainable control programmes which exist against parasitic diseases, especially in low income settings. Proteomics and nanotechnology approaches are valuable tools for sensing pathogens and host alteration signatures within microfluidic detection platforms. These new devices might provide novel solutions to fight parasitic diseases. Newly described specific parasite derived products with immune-modulatory properties have been postulated as the best candidates for the early and accurate detection of parasitic infections as well as for the blockage of parasite development. This review provides the most recent methodological and technological advances with great potential for bio-sen...Continue Reading

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Citations

May 29, 2018·Parasitology·Lígia Moraes Barizon de SouzaPaul A Bates
Mar 8, 2019·Scientific Reports·Mavys Tabraue-ChávezJuan José Díaz-Mochón
Jun 13, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Leticia Gomes de PontesLucilene Delazari Dos Santos
Aug 9, 2021·Acta Tropica·Idessania Nazareth CostaFabiana Martins de Paula

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