Sensing, Transport and Other Potential Biomedical Applications of Pseudopeptides

Current Medicinal Chemistry
Enrico FaggiIgnacio Alfonso

Abstract

Pseudopeptides are privileged synthetic molecules built from the designed combination of peptide-like and abiotic artificial moieties. Consequently, they are benefited from the advantages of both families of chemical structures: modular synthesis, chemical and functional diversity, tailored three-dimensional structure, usually high stability in biological media and low non-specific toxicity. Accordingly, in the last years, these compounds have been used for different biomedical applications, ranging from bio-sensing, ion transport, the molecular recognition of biologically relevant species, drug delivery or gene transfection. This review highlights a selection of the most remarkable and recent advances in this field.

References

May 26, 1972·Science·W L DuaxD A Norton
May 29, 1970·Science·M Ohnishi, D W Urry
May 22, 1969·Biochemical and Biophysical Research Communications·M PinkertonP Dawkins
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Oblatt-MontalM Montal
Sep 28, 2000·The Journal of Biological Chemistry·D M WilliamsP A Cole
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·L GaoH J Forman
Jul 27, 2001·Nature·S Fernandez-LopezM R Ghadiri
Apr 23, 2002·Current Medicinal Chemistry·Celine Adessi, Claudio Soto
Aug 29, 2002·Chemical Communications : Chem Comm·Yvonne R VandenburgNormand Voyer
Jun 25, 2003·Toxicology·Lisa M Gaetke, Ching Kuang Chow
Mar 17, 2004·Bioorganic & Medicinal Chemistry·Eric BironNormand Voyer
May 12, 2004·Current Medicinal Chemistry·Francisco SarabiaF Jorge López Herrera
May 21, 2004·American Journal of Physiology. Cell Physiology·James R BroughmanBruce D Schultz
Nov 17, 2004·Advances in Physiology Education·Walter F Boron
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Véronique DartoisThomas R Parr
Jan 5, 2006·Chemical Communications : Chem Comm·Robert PajewskiGeorge W Gokel
Mar 24, 2006·Nature·Frances M Ashcroft
Aug 22, 2006·Current Medicinal Chemistry·Luca GentilucciFederico Squassabia
Sep 20, 2006·Trends in Biochemical Sciences·Yasuhiro NoseDennis J Thiele
Feb 6, 2007·Lancet·Aftab AlaMichael L Schilsky
Apr 28, 2007·Organic & Biomolecular Chemistry·Pierre-Luc Boudreault, Normand Voyer
May 17, 2007·Journal of the American Chemical Society·Xiang LiDan Yang
Apr 29, 2008·Chemical Communications : Chem Comm·Pierre-Luc BoudreaultNormand Voyer
Feb 24, 2009·Investigative Ophthalmology & Visual Science·Jesica MartinBruce D Schultz
May 21, 2009·Journal of the American Chemical Society·Anaïs M PujolPascale Delangle
Jun 27, 2009·Chemical Communications : Chem Comm·Leila MotieiM Reza Ghadiri
Sep 24, 2009·Journal of the American Chemical Society·Xiang LiDan Yang
Oct 17, 2009·Chemical Reviews·Junyan Han, Kevin Burgess
Dec 10, 2009·Nature Reviews. Molecular Cell Biology·Joseph R CaseyJohn Orlowski
Apr 27, 2010·Chemical Society Reviews·Roberto J BreaJuan R Granja
May 15, 2010·Chemistry : a European Journal·Thomas FiehnStefan Kubik
Aug 5, 2010·Inorganic Chemistry·Salvador BlascoSantiago V Luis
Dec 16, 2010·Journal of the American Chemical Society·Anaïs M PujolPascale Delangle
Dec 18, 2010·Nature Reviews. Microbiology·Julian G HurdleRichard E Lee
Mar 10, 2011·Journal of the American Chemical Society·François OtisNormand Voyer
Jan 17, 2012·Journal of the American Chemical Society·Junchen WuCarsten Schmuck
Feb 7, 2012·Advanced Drug Delivery Reviews·George W Gokel, Saeedeh Negin
May 25, 2012·Nature Reviews. Cancer·Jessica B Casaletto, Andrea I McClatchey
Jun 26, 2012·Angewandte Chemie·Anaïs M PujolPascale Delangle

❮ Previous
Next ❯

Citations

Oct 5, 2019·Current Medicinal Chemistry·Yubin Ding

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved