PMID: 7032577Nov 1, 1981Paper

Sensitisation against environmental antigens and respiratory symptoms in swine workers

British Journal of Industrial Medicine
M L KatilaT H Ojanen

Abstract

Adverse effects caused by airborne material to the respiratory tract are due either to non-specific irritation or to hypersensitivity. In this study 20 people employed in swine barns and 18 controls were tested for sensitisation against dusts present in the barn. Immunoprecipitation and enzyme-linked immunoassay (ELISA) were used to test for IgG antibodies; IgE antibodies against swine epithelium were tested using solid phase radioimmunoassay. Precipitins against swine antigens were found in two swine workers; while ELISA found six to be sensitised. Sensitisation against swine antigens correlated with exposure but not with the presence of symptoms. No IgE antibodies were found. Precipitins against feed antigens were detected in 12 workers; in nine of the 12 with symptoms, and in three of the eight asymptomatic workers. No single antigen was of special importance as an inducer of sensitisation. Sensitisation against feed dusts in barns, as indicated by the presence of circulating antibodies, suggests an immunological background for persistent symptoms. A large antigen penal should be used in testing for sensitisation because of the many immunogenic dusts present in the air in swine barns.

References

May 1, 1979·Clinical Allergy·O D CuthbertW D Brighton

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Citations

Jan 1, 1990·American Journal of Industrial Medicine·K J Donham
Jan 1, 1990·American Journal of Industrial Medicine·R BrouwerP van Swieten
Dec 1, 1987·British Journal of Industrial Medicine·P BongersK Biersteker
Jul 29, 2003·Occupational and Environmental Medicine·J A HoppinD P Sandler
Mar 27, 2007·Environmental Health Perspectives·Dick HeederikJames A Merchant
Dec 1, 1991·Environmental Research·E ZuskinN Rienzi
Apr 1, 1991·Chest·C ZhouJ A Dosman
Jan 1, 1987·American Journal of Industrial Medicine·D L HolnessJ R Nethercott
Jan 1, 1986·American Journal of Industrial Medicine·K J Donham
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine
Sep 6, 2018·Journal of Neurogenetics·Milton P Charlton

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