PMID: 20953055Oct 19, 2010

Sensitive analysis of blonanserin, a novel antipsychotic agent, in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Tadashi OgawaHiroshi Seno


A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, blonanserin was analyzed by the system with a C(18) column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 0.01-10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.


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Related Concepts

High Pressure Liquid Chromatography Procedure
Mass Spectrometry
Antipsychotic Effect
Solid Phase Microextraction
Tandem Mass Spectrometry
Forensic Medicine

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