Sensitive biomarkers identification for differentiating Cd and Pb induced toxicity on zebrafish embryos

Environmental Toxicology and Pharmacology
Jian YinJin-Feng Wei

Abstract

Cadmium (Cd) and lead (Pb) are naturally existing heavy metals that pose significant health risks. The present study aims to identify sensitive biomarkers for differentiating the toxicities induced by Cd and Pb and for providing clues for the early prediction of toxicity and environmental risk assessment. Indicators related to oxidative stress and inflammatory responses in zebrafish treated with Cd and Pb over time (from 24hpf to 96hpf) were compared. Furthermore, endpoints such as embryo lethality and teratogenicity were detected. Then, several related genes involved in oxidative stress and inflammatory responses characterizing both Cd and Pb exposure, along with key molecules in the MAPKs pathway, were compared at the mRNA level, allowing the selection of the most sensitive and informative biomarkers. Significant increases in reactive oxygen species (ROS) production were observed in zebrafish exposed to Cd and Pb. Cd and Pb exposure induced developmental toxicity, influencing survival rate, hatching rate, larval growth, and heart rate and causing abnormal embryonic development. Similar trends in SOD1 and SOD2 gene expression were induced by Cd and Pb, while nuclear factor erythroid-2 related factor 2 (Nrf2) gene expression re...Continue Reading

Citations

Jun 20, 2018·Environmental Toxicology and Chemistry·Julie C KrzykwaMarlo K Sellin Jeffries
Jun 1, 2020·Bulletin of Environmental Contamination and Toxicology·Rui ZhengJufang Peng
Feb 20, 2021·Ecotoxicology and Environmental Safety·Huihui WuAijun Lin
Dec 18, 2018·Ecotoxicology and Environmental Safety·Julie C KrzykwaMarlo K Sellin Jeffries
May 1, 2021·International Journal of Environmental Research and Public Health·Cristina DinuLuoana Florentina Pascu
May 12, 2021·Ecotoxicology and Environmental Safety·Siyu XiaGuixue Wang
Aug 16, 2021·Environmental Toxicology and Pharmacology·Nikola MitovicJelena Nesovic Ostojic
Oct 22, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Andrew KatabaMayumi Ishizuka

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