Abstract
Exosomes are small extracellular vesicles released by cells for cell-cell communication. They play important roles in cancer development, metastasis, and drug resistance. Exosomal proteins have been demonstrated by many studies as promising biomarkers for cancer screening, diagnosis, and monitoring. Among many detection techniques, surface plasmon resonance (SPR) is a highly sensitive, label-free, and real-time optical detection method. Commercial prism-based wavelength/angular-modulated SPR sensors afford high sensitivity and resolution, but their large footprint and high cost limit their adaptability for clinical settings. Recently, a nanoplasmonic exosome (nPLEX) assay was developed to detect exosomal proteins for ovarian cancer diagnosis. However, comparing with conventional SPR biosensors, the broad applications of nanoplasmonic biosensors are limited by the difficult and expensive fabrication of nanostructures. We have developed an intensity-modulated, compact SPR biosensor (25 cm × 10 cm × 25 cm) which uses a conventional SPR sensing mechanism and does not require nanostructure fabrication. Calibration from glycerol showed that the compact SPR biosensor offered sensitivity of 9.258 × 103%/RIU and resolution of 8.311 × 10...Continue Reading
References
Nov 12, 2005·Journal of Industrial Microbiology & Biotechnology·Scott D SoelbergClement E Furlong
Jan 31, 2008·Chemical Reviews·Jirí Homola
Mar 13, 2010·Molecular & Cellular Proteomics : MCP·Joanne L WeltonAled Clayton
May 11, 2011·Electrophoresis·Yanyan LiZongyin Qiu
Nov 8, 2011·The Lancet Oncology·Robert PirkerKenneth J O'Byrne
May 28, 2013·Cancer Metastasis Reviews·Asfar S AzmiFazlul H Sarkar
Apr 23, 2014·Nature Biotechnology·Hyungsoon ImHakho Lee
May 23, 2014·Analytical Chemistry·Déborah L M RupertFredrik Höök
Jun 25, 2014·Current Opinion in Cell Biology·Joanna KowalClotilde Théry
Nov 19, 2014·Nature Reviews. Urology·Muhammad NawazThomas Kislinger
Mar 5, 2015·Journal of Extracellular Vesicles·Kristine R JakobsenMalene M Jørgensen
Mar 25, 2015·Scientific Reports·Onur TokelUtkan Demirci
May 1, 2015·Analytical and Bioanalytical Chemistry·Luigino GrassoHorst Vogel
May 6, 2015·Expert Review of Molecular Diagnostics·Hyungsoon ImHakho Lee
May 17, 2015·Journal of Extracellular Vesicles·María Yáñez-MóOlivier De Wever
Jun 25, 2015·Nature·Sonia A MeloRaghu Kalluri
Aug 11, 2015·Scientific Reports·Yun LiuWei Peng
Sep 20, 2012·The Journal of Physical Chemistry Letters·Giuseppe Spoto, Maria Minunni
Dec 10, 2015·Lab on a Chip·Zheng ZhaoMei He
Jan 8, 2016·Journal of Proteomics·David J ClarkLi Mao
Mar 12, 2016·Cell·Mercedes Tkach, Clotilde Théry
Jun 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Birgitte Sandfeld-PaulsenBoe Sandahl Sorensen
Jul 29, 2016·Scientific Reports·Abu Ali Ibn SinaMatt Trau
Nov 10, 2016·Sensors·Shun WangJiandong Hu
Nov 20, 2016·Molecular Oncology·B Sandfeld-PaulsenB S Sorensen
Jun 21, 2017·Sensors·Xiao-Ling ZhangJun Yang
Aug 31, 2017·Molecular Cancer·Weihua LiDexi Chen
Sep 2, 2017·Scientific Reports·Minghui ZhangYan Wang
Mar 14, 2018·Clinical Lung Cancer·Fausto PetrelliMatteo Brighenti
Citations
Feb 6, 2019·Analytical and Bioanalytical Chemistry·Abu Ali Ibn SinaMatt Trau
Apr 2, 2020·Mikrochimica Acta·Guofu LiaoKemin Wang
Aug 27, 2019·Frontiers in Chemistry·Noemi BellassaiGiuseppe Spoto
Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·Houman Kholafazad Kordasht, Mohammad Hasanzadeh
Sep 6, 2019·The Analyst·Yinqiang XiaZhimin He
Dec 7, 2019·Journal of Extracellular Vesicles·Shin La ShuMarc S Ernstoff
Dec 5, 2020·Journal of Cellular Physiology·Benhui LiangMujun Liu
Jan 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jonalyn DeCastroKiana Aran
Nov 13, 2020·Frontiers in Cell and Developmental Biology·Kaijian ZhouGuoxin Liang
Feb 27, 2021·Analytical and Bioanalytical Chemistry·Cristina Muñoz-San MartínSusana Campuzano
May 5, 2020·Biosensors & Bioelectronics·Lizhou XuKhuloud T Al Jamal
Apr 9, 2021·Seminars in Cancer Biology·Xiaoming DaiWenyi Wei
Apr 27, 2021·Bioactive Materials·Komal AbhangeYuan Wan
Apr 23, 2021·Advanced Drug Delivery Reviews·Alice GualerziMarzia Bedoni
Jul 23, 2021·Expert Review of Molecular Diagnostics·Beata OlejnikMirosława Ferens-Sieczkowska
Aug 7, 2021·Biosensors·Chia-Chen Chang
Oct 30, 2020·ACS Nano·Lip Ket ChinHyungsoon Im
Sep 9, 2021·ACS Sensors·Chuanyu WangPengyu Chen
Nov 27, 2021·Journal of Cellular Physiology·Seyed Z RasihashemiParisa Lotfinejad
Dec 2, 2021·ACS Applied Nano Materials·Yunchen YangYun Wu
Jan 25, 2022·Analytical Chemistry·Jugal SutharStefan Guldin