Sensitivities of major causative organisms isolated from patients with acute uncomplicated cystitis against various antibacterial agents: results of subanalysis based on the presence of menopause

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Tetsuro MatsumotoShingo Yamamoto

Abstract

We investigated whether the presence of menopause influenced the species and distribution of causative bacteria isolated from patients with acute uncomplicated cystitis (the most common urinary tract infection), and we also investigated the sensitivity of the isolated species to antibacterial agents. Using multivariate analysis, we also investigated risk factors for infection with quinolone-resistant Escherichia coli, because its frequency has increased and it is now a clinical problem in Japan. Six hundred and thirty-four strains were isolated from 489 premenopausal patients (mean age 32.3 ± 10.1 years). Major causative bacteria detected were Escherichia coli (65.0 %), Enterococcus faecalis (12.0 %), Streptococcus agalactiae (5.5 %), and Klebsiella pneumoniae (1.6 %). From 501 postmenopausal patients (mean age 68.7 ± 10.29 years), 657 strains were isolated, and the major causative bacteria detected were E. coli (61.5 %), E. faecalis (13.7 %), K. pneumoniae (5.2 %), and S. agalactiae (4.0 %). The sensitivities to fluoroquinolones (FQs) and cephems of E. coli isolated from premenopausal patients were both ≥90 %, while the sensitivities to FQs of E. coli isolated from postmenopausal patients were about 5 % lower. In regard to inf...Continue Reading

References

Sep 22, 2005·The Journal of Antimicrobial Chemotherapy·Hande ArslanUNKNOWN Urinary Tract Infection Study Group
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James H Jorgensen, Janet F Hindler
Jan 19, 2011·International Journal of Antimicrobial Agents·Tetsuro MatsumotoShingo Yamamoto

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Citations

Nov 15, 2013·The New England Journal of Medicine·Thomas M HootonAnn E Stapleton
Jul 15, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kiyohito IshikawaYohei Matsuda
Jul 3, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ryoichi HamasunaMasaru Yoshioka
Apr 23, 2015·Infectious Diseases·Rôde B B SchuabRosana R Barros
Apr 18, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Koichiro WadaShingo Yamamoto

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