Sensitivity analysis and parametric study of elastic properties of an unidirectional mineralized bone fibril-array using mean field methods

Biomechanics and Modeling in Mechanobiology
Andreas G ReisingerPhilippe K Zysset

Abstract

The key parameters determining the elastic properties of an unidirectional mineralized bone fibril-array decomposed in two further hierarchical levels are investigated using mean field methods. Modeling of the elastic properties of mineralized micro- and nanostructures requires accurate information about the underlying topology and the constituents' material properties. These input data are still afflicted by great uncertainties and their influence on computed elastic constants of a bone fibril-array remains unclear. In this work, mean field methods are applied to model mineralized fibrils, the extra-fibrillar matrix and the resulting fibril-array. The isotropic or transverse isotropic elastic constants of these constituents are computed as a function of degree of mineralization, mineral distribution between fibrils and extra-fibrillar matrix, collagen stiffness and fibril volume fraction. The linear sensitivity of the elastic constants was assessed at a default set of the above parameters. The strain ratios between the constituents as well as the axial and transverse indentation moduli of the fibril-array were calculated for comparison with experiments. Results indicate that the degree of mineralization and the collagen stiffn...Continue Reading

References

Mar 13, 1979·Calcified Tissue International·S Lees
Nov 25, 1979·Journal of Molecular Biology·S Cusack, A Miller
Mar 1, 1988·Calcified Tissue International·M M Giraud-Guille
Nov 1, 1993·Journal of Biomechanical Engineering·J L Katz, A Meunier
Mar 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D E BirkR L Trelstad
Jul 29, 1998·Medical Engineering & Physics·J Y RhoP Zioupos
Sep 4, 1999·Journal of Structural Biology·S WeinerH D Wagner
Jan 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S J EppellM J Glimcher
May 11, 2002·Archives of Histology and Cytology·Mario RaspantiStefano Guizzardi
Dec 18, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·William J Landis, Frederick H Silver
Sep 23, 2003·Journal of Biomechanics·Frederick H SilverGurinder P Seehra
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·Naoki SasakiKunio Hikichi
Sep 8, 2005·Journal of Biomechanics·Tobias HofmannKay Raum
Oct 13, 2005·Nano Letters·Himadri S GuptaPeter Fratzl
Mar 1, 1969·Journal of Biomechanics·J D Currey
Jun 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Joseph P R O OrgelTim J Wess
Sep 13, 2006·Macromolecular Bioscience·Joost A J van der RijtJan Feijen
Nov 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Himadri S GuptaPeter Fratzl
Feb 14, 2007·Biomechanics and Modeling in Mechanobiology·Young June Yoon, Stephen C Cowin
Mar 1, 2006·Biointerphases·W WagermaierP Fratzl

❮ Previous
Next ❯

Citations

Apr 25, 2012·Biomechanics and Modeling in Mechanobiology·J J Schwiedrzik, P K Zysset
Jun 25, 2013·Biomechanics and Modeling in Mechanobiology·Ana VercherF Javier Fuenmayor
Mar 22, 2014·Current Osteoporosis Reports·Kay RaumPascal Laugier
Jun 8, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Eugenio GinerF Javier Fuenmayor
Jan 23, 2014·Biomechanics and Modeling in Mechanobiology·Sara TiburtiusAlf Gerisch
Apr 30, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Ewa M Spiesz, Philippe K Zysset
Nov 12, 2013·Journal of the Mechanical Behavior of Biomedical Materials·S PucheggerR Weinkamer
Jun 6, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Ewa M SpieszPhilippe K Zysset
Dec 17, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Ana Vercher-MartínezF Javier Fuenmayor
Apr 2, 2011·Journal of Biomechanics·Quentin GrimalPascal Laugier
May 9, 2012·Computer Methods in Biomechanics and Biomedical Engineering·Lukas EberhardsteinerStefan Scheiner
Oct 8, 2016·Current Osteoporosis Reports·Dieter H Pahr, Philippe K Zysset
May 8, 2020·Biomechanics and Modeling in Mechanobiology·Andreas G ReisingerDieter H Pahr
May 2, 2017·Annual Review of Biomedical Engineering·Gang Seob Jung, Markus J Buehler
Sep 1, 2016·BoneKEy Reports·Uwe Wolfram, Jakob Schwiedrzik
Jan 13, 2012·Science and Technology of Advanced Materials·Shigeru Tadano, Bijay Giri
May 14, 2017·Biomechanics and Modeling in Mechanobiology·Francesc Levrero-FlorencioPankaj Pankaj
May 20, 2020·Acta Biomaterialia·Daniele CasariJakob Schwiedrzik
Sep 5, 2019·ACS Central Science·Alessandra ProcopioStefano Iotti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.