Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-Based Model of Immune Responses to Helicobacter pylori Infection

PloS One
Maksudul AlamMadhav Marathe

Abstract

Agent-based models (ABM) are widely used to study immune systems, providing a procedural and interactive view of the underlying system. The interaction of components and the behavior of individual objects is described procedurally as a function of the internal states and the local interactions, which are often stochastic in nature. Such models typically have complex structures and consist of a large number of modeling parameters. Determining the key modeling parameters which govern the outcomes of the system is very challenging. Sensitivity analysis plays a vital role in quantifying the impact of modeling parameters in massively interacting systems, including large complex ABM. The high computational cost of executing simulations impedes running experiments with exhaustive parameter settings. Existing techniques of analyzing such a complex system typically focus on local sensitivity analysis, i.e. one parameter at a time, or a close "neighborhood" of particular parameter settings. However, such methods are not adequate to measure the uncertainty and sensitivity of parameters accurately because they overlook the global impacts of parameters on the system. In this article, we develop novel experimental design and analysis techniq...Continue Reading

References

Feb 1, 1995·Health Physics·D M Hamby
Aug 2, 2000·Critical Care Medicine·A J Seely, N V Christou
Aug 18, 2001·Cell·A Lanzavecchia, F Sallusto
Jun 29, 2002·Risk Analysis : an Official Publication of the Society for Risk Analysis·H Christopher Frey, Sumeet R Patil
Apr 12, 2003·Science·Susan M Kaech, Rafi Ahmed
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ulas KaraozSimon Kasif
May 14, 2004·Nature·Stephen EubankNan Wang
Jul 19, 2005·Nature Immunology·Amanda L MarzoLeo Lefrançois
Aug 17, 2006·Shock·Yoram VodovotzGilles Clermont
Mar 21, 2007·Immunological Reviews·Stephanie Forrest, Catherine Beauchemin
Apr 10, 2007·Cellular Immunology·V BaldazziM Bernaschi
Sep 22, 2007·Bulletin of Mathematical Biology·E BonabeauJ L Deneubourg
Oct 24, 2007·PLoS Pathogens·Karen A DucaDavid A Thorley-Lawson
Nov 1, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Qi MiYoram Vodovotz
Nov 7, 2007·Journal of Leukocyte Biology·Stephen F Lowry, Steve E Calvano
Mar 21, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Gary AnYoram Vodovotz
Mar 29, 2008·Journal of Theoretical Biology·M ShapiroD A Thorley-Lawson
Feb 18, 2010·Information Sciences·Amy L BauerAlan S Perelson
Oct 19, 2010·Journal of Biological Dynamics·Stephen EubankPaula Stretz
Oct 28, 2010·Deutsche medizinische Wochenschrift·M VeneritoP Malfertheiner
Dec 16, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hua LiHildegund C J Ertl
Oct 21, 2011·Clinical and Vaccine Immunology : CVI·Thomas WexPeter Malfertheiner
Feb 10, 2012·Journal of the Royal Society, Interface·T SumnerA Warner
Apr 12, 2012·Journal of the Royal Society, Interface·T SumnerI D L Bogle
Sep 19, 2012·IEEE Transactions on Nanobioscience·Katherine V WendelsdorfMadhav Marathe
Dec 12, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Deo R SinghValerică Raicu
Dec 12, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Douglas A Lauffenburger

❮ Previous
Next ❯

Citations

Sep 12, 2017·Environmental Microbiology·Aimée ParkerCarmen Pin
Jun 12, 2019·GigaScience·Meghna VermaRaquel Hontecillas
Jul 2, 2019·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Yoram Vodovotz, Gary An
Apr 4, 2021·Journal of Clinical Medicine·Vida AbediRamin Zand
Apr 20, 2021·Frontiers in Neurology·Negar DarabiVida Abedi

❮ Previous
Next ❯

Software Mentioned

ENISI
ENISI MSM
MPICH2
ENISI HPC
ENISI Visual

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Angelman Syndrome

Angelman syndrome is a neurogenetic imprinting disorder caused by loss of the maternally inherited UBE3A gene and is characterized by generalized epilepsy, limited expressive speech, sleep dysfunction, and movement disorders. Here is the latest research.