Sensitivity and specificity of human brain glutathione concentrations measured using short-TE (1)H MRS at 7 T

NMR in Biomedicine
Dinesh K DeelchandMelissa Terpstra

Abstract

Although the MR editing techniques that have traditionally been used for the measurement of glutathione (GSH) concentrations in vivo address the problem of spectral overlap, they suffer detriments associated with inherently long TEs. The purpose of this study was to characterize the sensitivity and specificity for the quantification of GSH concentrations without editing at short TE. The approach was to measure synthetically generated changes in GSH concentrations from in vivo stimulated echo acquisition mode (STEAM) spectra after in vitro GSH spectra had been added to or subtracted from them. Spectra from five test subjects were synthetically altered to mimic changes in the GSH signal. To account for different background noise between measurements, retest spectra (from the same individuals as used to generate the altered data) and spectra from five other individuals were compared with the synthetically altered spectra to investigate the reliability of the quantification of GSH concentration. Using STEAM spectroscopy at 7 T, GSH concentration differences on the order of 20% were detected between test and retest studies, as well as between differing populations in a small sample (n = 5) with high accuracy (R(2) > 0.99) and certai...Continue Reading

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Citations

Aug 30, 2016·Nutritional Neuroscience·Claire J ScavuzzoRyan J Larsen
Dec 31, 2016·Analytical Biochemistry·Wolfgang BognerOvidiu C Andronesi
Nov 11, 2017·Neuro-oncology·Francesca BranzoliMalgorzata Marjanska
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Jul 17, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dunja SimicicCristina Cudalbu

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