Sensitivity and specificity of mean corpuscular volume testing for screening for alpha-thalassemia-1 and beta-thalassemia traits

The Journal of Obstetrics and Gynaecology Research
Supatra SirichotiyakulTheera Tongsong

Abstract

To evaluate the sensitivity, specificity, positive predictive value and negative predictive value of mean corpuscular volume (MCV) testing for screening for both alpha-thalassemia-1 and beta-thalassemia traits. A diagnostic test was conducted on 439 pregnant women attending the antenatal care (ANC) clinic at Maharaj Nakorn Chiang Mai Hospital between April 2002 and July 2002. Blood samples were collected from the pregnant women after they were counseled and gave informed consent. The MCV was measured in all samples using an automated hematology analyzer. The hemoglobin (HbA2) level and polymerase chain reaction (PCR) were measured in all cases to test for the beta-thalassemia trait and the alpha-thalassemia-1 gene (South-East Asian [SEA] type), respectively. The data were collected and analyzed for sensitivity, specificity, positive predictive value and negative predictive value for evaluating the efficacy of MCV testing for screening for both alpha-thalassemia-1 and beta-thalassemia traits. Positive MCV tests (</=80 fl) showed a sensitivity of 92.9% and specificity of 83.9% in screening for alpha-thalassemia-1 and beta-thalassemia traits, respectively. The positive predictive value and negative predictive value were 37.9% and ...Continue Reading

References

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Citations

Jan 13, 2010·International Journal of Hematology·Surakit KuntarukWatchara Kasinrerk
Jul 14, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Supatra SirichotiyakulTheera Tongsong
Dec 14, 2005·The Journal of Obstetrics and Gynaecology Research·Yong-Chui WeeJin-Ai Mary Anne Tan
Apr 5, 2013·Prenatal Diagnosis·Theera TongsongSavitree Pranpanus
Oct 20, 2015·Archives of Gynecology and Obstetrics·Chitrakan CharoenboonTheera Tongsong
Jun 1, 2016·The Indian Journal of Medical Research·Somphon PharephanLuksana Makonkawkeyoon
Jun 11, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Kuntharee TraisrisilpTheera Tongsong
Dec 20, 2008·American Journal of Clinical Pathology·Zhaohai YangVishnu V B Reddy
Dec 3, 2009·The Nurse Practitioner·Melissa Santiago
Dec 17, 2009·Transfusion Medicine·A K TiwariA Ahuja
Nov 28, 2013·Journal of Pediatric Hematology/oncology·A A Nilanga NishadAnuja P Premawardhena
Feb 21, 2020·The Journal of Obstetrics and Gynaecology Research·Chanhathai NunchaiTheera Tongsong

Related Concepts

Mean Corpuscular Hemoglobin Concentration Determination
Pregnancy Complications, Hematologic
Antenatal Screening Procedures
Alpha-Thalassemia
Thalassemia Minor

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