Sensitivity and Specificity of Metal Ion Level in Predicting Adverse Local Tissue Reactions Due to Head-Neck Taper Corrosion in Primary Metal-on-Polyethylene Total Hip Arthroplasty

The Journal of Arthroplasty
Young-Min KwonYun Peng

Abstract

There is increasing concern regarding the occurrence of adverse local tissue reactions (ALTRs) in metal-on-polyethylene (MoP) total hip arthroplasty (THA) patients due to mechanically assisted crevice corrosion at the head-neck modular taper junction. The utility of metal ion levels in evaluating MoP patients with head-neck taper has not been fully characterized. This study aimed to investigate the sensitivity and specificity of serum metal ions as a predictor of ALTR in MoP THA patients. A total of 62 MoP THA patients in 2 cohorts were investigated: (1) ALTR on metal artifact reduction sequence magnetic resonance imaging (n = 43) and (2) without ALTR on metal artifact reduction sequence magnetic resonance imaging (n = 19). Receiver-operating characteristic curve was constructed to determine the sensitivity and specificity using different metal ion thresholds and the optimal metal ion cutoff values. The presence of ALTR was associated with significantly higher cobalt (8.9 ng/mL vs 0.3 ng/mL, P < .001), chromium (2.26 ng/mL vs 0.21 ng/mL, P < .001), and Co/Cr ratio (5.9 vs 2.0, P < .001). The sensitivity and specificity for cobalt (1 ng/mL) was 95% and 94% and for Co/Cr ratio (2) was 83% and 72%, respectively. Although metal ion...Continue Reading

Citations

Dec 11, 2019·Zeitschrift für Orthopädie und Unfallchirurgie·Jörg LütznerMichael Morlock
Oct 1, 2019·The Journal of Bone and Joint Surgery. American Volume·Mengnai Li, Andrew Glassman
Oct 6, 2020·Physiological Genomics·Yuan WenCharlotte A Peterson
Jun 23, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Tahsin M RahmanCraig D Silverton
Jun 10, 2021·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Kristine I BunyozAnders Troelsen
Sep 21, 2021·Biomarkers in Medicine·Ivan J VechettiCharlotte A Peterson
Nov 2, 2021·Archives of Orthopaedic and Trauma Surgery·Anna Jungwirth-WeinbergerFriedrich Boettner

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