PMID: 8600964Mar 1, 1996Paper

Sensitivity and specificity of MR mammography with histopathological correlation in 250 breasts

Acta Radiologica
B BonéB Veress

Abstract

The aim of our prospective study was to determine the diagnostic accuracy of MR mammography (MRM) in detecting malignant disease. In 231 consecutive patients scheduled for surgery because of mammographic or palpable lesions suspected of malignancy, the breasts were examined with T1-weighted transversal images using a 3-D fast low angle shot (FLASH) sequence. One pre- and 2 post-contrast images were obtained. Histological examination of the surgical specimens showed carcinoma in 155 breasts, of which 138 were invasive and 17 in situ. MRM detected 144 of the 155 malignancies and was false-negative in 11 cases. Eight of these MRM-missed tumours were invasive and 3 were in situ cancers. Benign lesions were found at microscopy in 95 breasts, of which MRM correctly diagnosed 69. The cellular composition of the 26 false-positive lesions (myxomatous stromal change, high vascularity, and epithelial or apocrine hyperplasia) might explain the false positivity. The sensitivity and specificity of MRM were 93% and 73% respectively. MRM should be interpreted with caution, and supplemented with e.g. mammography and ultrasonography.

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Citations

Aug 5, 2014·Diagnostic and Interventional Imaging·J MercierS Lemery
May 13, 2008·Journal of the American College of Surgeons·Stephen R GrobmyerWilliam G Cance
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Mar 16, 2004·European Radiology·F SardanelliA Fausto
Sep 26, 2003·Journal of Magnetic Resonance Imaging : JMRI·Milica MedvedGregory S Karczmar
Nov 2, 2018·AJR. American Journal of Roentgenology·Hannah PerryTejas S Mehta
Jan 12, 2019·Journal of Magnetic Resonance Imaging : JMRI·Victoria L MangoRichard Ha
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Mar 5, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Rimma DanielssonPeter Aspelin

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