Sensitivity and specificity of recombinant omega-5 gliadin-specific IgE measurement for the diagnosis of wheat-dependent exercise-induced anaphylaxis

Allergy
H MatsuoE Morita

Abstract

A recent study has shown that the measurement of specific IgE antibodies to B-cell epitope peptides of wheat omega-5 gliadin (Pep A) and high molecular weight glutenin subunit (Pep B) are useful to diagnose wheat-dependent exercise-induced anaphylaxis (WDEIA). We sought to compare the sensitivity and specificity of the in vitro tests for measuring the specific IgE antibodies to recombinant omega-5 gliadin (romega-5 gliadin) with those for wheat, gluten, Pep A, and Pep B in identification of patients with WDEIA. Fifty patients with WDEIA, 25 healthy subjects and 25 patients with atopic dermatitis with specific IgE antibodies to wheat but without experience of allergic reactions after ingestion of wheat products were enrolled in this study. The concentrations of specific IgE antibodies were measured using ImmunoCAP. The empirical receiver operating characteristics curves (ROC) for each test were prepared and the areas under the ROC curve (AUC) were compared. In patients with WDEIA, the sensitivities of the allergen-specific IgE tests for wheat, gluten, Pep A, Pep B and romega-5 gliadin were 48%, 56%, 76%, 22%, and 80%, respectively. The seven of 10 WDEIA patients with no specific IgE antibodies to romega-5 gliadin had specific Ig...Continue Reading

References

Dec 2, 1983·JAMA : the Journal of the American Medical Association·E M BuchbinderT E Guiney
Apr 1, 1983·The Journal of Allergy and Clinical Immunology·J M KiddJ N Fink
May 18, 1999·The Journal of Allergy and Clinical Immunology·K PalosuoT Reunala
May 10, 2001·The Journal of Allergy and Clinical Immunology·H A Sampson
Jul 17, 2001·The British Journal of Dermatology·E MoritaS Yamamoto
Oct 9, 2001·The Journal of Allergy and Clinical Immunology·K PalosuoT Reunala
Jul 4, 2003·Current Opinion in Allergy and Clinical Immunology·Kati Palosuo
Apr 20, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H MatsuoE Morita
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroaki MatsuoEishin Morita

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Citations

Nov 13, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R BransH F Merk
Oct 29, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·P Schmid-Grendelmeier
Nov 29, 2012·Current Allergy and Asthma Reports·Emily C McGowan, Sarbjit Saini
Oct 16, 2013·Current Allergy and Asthma Reports·Gabriel K Wong, Mamidipudi T Krishna
May 15, 2013·Journal of Dermatological Science·Eishin MoritaHitoshi Takahashi
Oct 12, 2011·International Archives of Allergy and Immunology·Han-Jung ParkHae-Sim Park
Oct 15, 2011·Journal of Occupational Health·Iraj KhodadadiEffat Sadat Mirmoeini
Apr 24, 2014·Arerugī = [Allergy]·Makiko Hiragun, Mitsuhiro Sakae
Jul 2, 2014·Postgraduate Medical Journal·Meera ThalayasingamLynette Pei-Chi Shek
Jan 1, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Tiffany WongEdmond S Chan
Dec 3, 2014·Immunology and Allergy Clinics of North America·Jacob D Kattan, Scott H Sicherer
Jul 4, 2008·Current Opinion in Allergy and Clinical Immunology·Kathrin SchererAndreas J Bircher
Mar 26, 2009·Current Opinion in Allergy and Clinical Immunology·Naoko Inomata
Dec 17, 2015·Expert Review of Clinical Immunology·Niti Y Chokshi, Scott H Sicherer
Jan 23, 2016·Expert Review of Clinical Immunology·Santiago QuirceAraceli Díaz-Perales
Jan 29, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Inmaculada Pérez-RangelSilvia Irene Corrales-Vargas
Sep 19, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Katharina Anne ScherfHerbert Wieser
Apr 3, 2012·The Journal of Allergy and Clinical Immunology·Yuko ChinukiEishin Morita
Jan 17, 2012·Immunology and Allergy Clinics of North America·Jean-Christoph Caubet, Hugh A Sampson
Jan 5, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·John M WeilerUNKNOWN Joint Council of Allergy, Asthma and Immunology
Oct 25, 2008·Journal of Dermatological Science·Hiroaki MatsuoEishin Morita
Jul 16, 2008·The Journal of Allergy and Clinical Immunology·Kirsten BeyerHugh A Sampson
Oct 31, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A RomanoA Mari
Jul 21, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Magnus P BorresPhilippe A Eigenmann
Jul 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L TuckovaP Panzner
Mar 16, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S PahrR Valenta
Dec 5, 2015·The World Allergy Organization Journal·Peter K SmithPhil Lieberman
Oct 5, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroaki MatsuoTakanori Taogoshi
Nov 29, 2011·Journal of the American Dietetic Association·Isabel Skypala
Jul 18, 2015·Journal of Agricultural and Food Chemistry·Hamza MameriSandra Denery-Papini
Jul 28, 2015·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Nilhan Rajiva de SilvaGathsauri Neelika Malavige
Mar 6, 2015·Clinical and Translational Allergy·Isabel J SkypalaUNKNOWN Allergy-focussed Diet History Task Force of the European Academy of Allergy and Clinical Immunology
Oct 25, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Yuko Chinuki, Eishin Morita
Apr 25, 2013·Allergology International : Official Journal of the Japanese Society of Allergology·Kunie KohnoEishin Morita
Apr 4, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Tomoharu YokoojiHiroaki Matsuo
Oct 23, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Eishin MoritaAkira Tanaka
Feb 26, 2009·Allergology International : Official Journal of the Japanese Society of Allergology·Reiko TokudaTakao Fujisawa
Apr 23, 2015·Current Opinion in Allergy and Clinical Immunology·Sakura SatoMotohiro Ebisawa
Nov 23, 2013·Journal of Korean Medical Science·Young-Hee NamHae-Sim Park
Apr 23, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Kunie KohnoEishin Morita
Oct 2, 2014·The Journal of Allergy and Clinical Immunology·Knut BrockowJohannes Ring
Apr 7, 2015·Immunology and Allergy Clinics of North America·Anna M Feldweg
Feb 23, 2013·Clinical Nutrition Research·Seung-Eun LeeYoon-Seok Chang
Apr 10, 2016·Internal Medicine Journal·T A LeW B Smith

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