Sensitivity and Specificity of the Coma Recovery Scale--Revised Total Score in Detection of Conscious Awareness

Archives of Physical Medicine and Rehabilitation
Yelena G BodienJoseph T Giacino

Abstract

To describe the sensitivity and specificity of Coma Recovery Scale-Revised (CRS-R) total scores in detecting conscious awareness. Data were retrospectively extracted from the medical records of patients enrolled in a specialized disorders of consciousness (DOC) program. Sensitivity and specificity analyses were completed using CRS-R-derived diagnoses of minimally conscious state (MCS) or emerged from minimally conscious state (EMCS) as the reference standard for conscious awareness and the total CRS-R score as the test criterion. A receiver operating characteristic curve was constructed to demonstrate the optimal CRS-R total cutoff score for maximizing sensitivity and specificity. Specialized DOC program. Patients enrolled in the DOC program (N=252, 157 men; mean age, 49y; mean time from injury, 48d; traumatic etiology, n=127; nontraumatic etiology, n=125; diagnosis of coma or vegetative state, n=70; diagnosis of MCS or EMCS, n=182). Not applicable. Sensitivity and specificity of CRS-R total scores in detecting conscious awareness. A CRS-R total score of 10 or higher yielded a sensitivity of .78 for correct identification of patients in MCS or EMCS, and a specificity of 1.00 for correct identification of patients who did not me...Continue Reading

References

Oct 1, 1991·Archives of Physical Medicine and Rehabilitation·J T GiacinoK D Cicerone
Apr 14, 2005·Archives of Physical Medicine and Rehabilitation·Michele H LammiChristine M Taylor
Oct 29, 2010·Neurology·D Rodriguez MorenoJ Hirsch
Dec 20, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Konstantinos MargetisDamianos E Sakas
Sep 23, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sergio BagnatoGiuseppe Galardi

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Citations

May 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Anna EstraneoLuigi Trojano
Apr 13, 2017·Neuropsychological Rehabilitation·Sarah WannezSteven Laureys
May 26, 2017·Annals of Neurology·Sarah WannezUNKNOWN Coma Science Group collaborators
Jan 18, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D T Wade
Jul 20, 2019·Brain Injury : [BI]·Jitka AnnenCamille Chatelle
Jan 5, 2020·Neurocritical Care·Camille ChatelleBrian L Edlow
Aug 12, 2017·Restorative Neurology and Neuroscience·Antonino NaroRocco Salvatore Calabrò
May 26, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E G MochalovaM A Piradov
Feb 25, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D KondziellaUNKNOWN EAN Panel on Coma, Disorders of Consciousness
Apr 9, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Yun Ho ChoiTaewon Kim
Dec 31, 2019·Brain Communications·Corinne A BarehamSrivas Chennu
Apr 20, 2019·BMC Neurology·Lucia Francesca LuccaAntonio Cerasa
Mar 27, 2021·Surgical Neurology International·Jitender ChaturvediBernard R Bendok
Sep 30, 2020·Annals of Physical and Rehabilitation Medicine·Charlène AubinetCamille Chatelle

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